Wang Y - Search Results

1

Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.

Wang Y, Wang C, Liu T, Qi H, Chen S, Cai X, Zhang M, Aliper A, Ren F, Ding X, Zhavoronkov A. Wang Y, et al. Among authors: wang c. J Med Chem. 2024 Jan 11;67(1):420-432. doi: 10.1021/acs.jmedchem.3c01476. Epub 2023 Dec 26. J Med Chem. 2024. PMID: 38146659

2

Pyrrolo[2,3-b]pyridine derivatives as potent Bruton's tyrosine kinase inhibitors.

Zhao X, Huang W, Wang Y, Xin M, Jin Q, Cai J, Tang F, Zhao Y, Xiang H. Zhao X, et al. Among authors: wang y. Bioorg Med Chem. 2015 Aug 1;23(15):4344-4353. doi: 10.1016/j.bmc.2015.06.023. Epub 2015 Jun 17. Bioorg Med Chem. 2015. PMID: 26169764

3

Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer.

Zhang X, Wang Y, Li X, Wu J, Zhao L, Li W, Liu J. Zhang X, et al. Among authors: wang y. J Med Chem. 2021 Jun 10;64(11):7575-7595. doi: 10.1021/acs.jmedchem.1c00280. Epub 2021 May 31. J Med Chem. 2021. PMID: 34056898

4

Discovery of 1,6-Naphthyridin-2(1H)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma.

Zhang X, Wang Y, Ji J, Si D, Bao X, Yu Z, Zhu Y, Zhao L, Li W, Liu J. Zhang X, et al. Among authors: wang y. J Med Chem. 2022 Jun 9;65(11):7595-7618. doi: 10.1021/acs.jmedchem.1c01977. Epub 2022 May 29. J Med Chem. 2022. PMID: 35635004

5

Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors.

Wang Y, Wang C, Liu J, Sun D, Meng F, Zhang M, Aliper A, Ren F, Zhavoronkov A, Ding X. Wang Y, et al. Among authors: wang c. Bioorg Med Chem. 2024 Apr 1;103:117662. doi: 10.1016/j.bmc.2024.117662. Epub 2024 Mar 6. Bioorg Med Chem. 2024. PMID: 38493730

6

Discovery of macrocyclic CDK2/4/6 inhibitors with improved potency and DMPK properties through a highly efficient macrocyclic drug design platform.

Meng F, Liu J, Cao Z, Yu J, Steurer B, Yang Y, Wang Y, Cai X, Zhang M, Ren F, Aliper A, Ding X, Zhavoronkov A. Meng F, et al. Among authors: wang y. Bioorg Chem. 2024 May;146:107285. doi: 10.1016/j.bioorg.2024.107285. Epub 2024 Mar 15. Bioorg Chem. 2024. PMID: 38547721

7

Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer.

Wang C, Wang Y, Meng F, Liu T, Wang X, Cai X, Zhang M, Aliper A, Ren F, Zhavoronkov A, Ding X. Wang C, et al. Among authors: wang x, wang y. Eur J Med Chem. 2025 Jan 5;281:117025. doi: 10.1016/j.ejmech.2024.117025. Epub 2024 Nov 5. Eur J Med Chem. 2025. PMID: 39515174

8

Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors.

Zhao X, Xin M, Huang W, Ren Y, Jin Q, Tang F, Jiang H, Wang Y, Yang J, Mo S, Xiang H. Zhao X, et al. Among authors: wang y. Bioorg Med Chem. 2015 Jan 15;23(2):348-64. doi: 10.1016/j.bmc.2014.11.006. Epub 2014 Nov 10. Bioorg Med Chem. 2015. PMID: 25515957

9

Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold.

Zhao X, Huang W, Wang Y, Xin M, Jin Q, Cai J, Tang F, Zhao Y, Xiang H. Zhao X, et al. Among authors: wang y. Bioorg Med Chem. 2015 Feb 15;23(4):891-901. doi: 10.1016/j.bmc.2014.10.043. Epub 2014 Nov 6. Bioorg Med Chem. 2015. PMID: 25596757

10

Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton's tyrosine kinase (BTK) inhibitors.

Zhao X, Xin M, Wang Y, Huang W, Jin Q, Tang F, Wu G, Zhao Y, Xiang H. Zhao X, et al. Among authors: wang y. Bioorg Med Chem. 2015 Sep 1;23(17):6059-68. doi: 10.1016/j.bmc.2015.05.043. Epub 2015 May 31. Bioorg Med Chem. 2015. PMID: 26277759

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