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Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates.
Harris KL, Thomson RES, Gumulya Y, Foley G, Carrera-Pacheco SE, Syed P, Janosik T, Sandinge AS, Andersson S, Jurva U, Bodén M, Gillam EMJ. Harris KL, et al. Among authors: foley g. Mol Biol Evol. 2022 Jun 2;39(6):msac116. doi: 10.1093/molbev/msac116. Mol Biol Evol. 2022. PMID: 35639613 Free PMC article.
Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP).
Foley G, Mora A, Ross CM, Bottoms S, Sützl L, Lamprecht ML, Zaugg J, Essebier A, Balderson B, Newell R, Thomson RES, Kobe B, Barnard RT, Guddat L, Schenk G, Carsten J, Gumulya Y, Rost B, Haltrich D, Sieber V, Gillam EMJ, Bodén M. Foley G, et al. PLoS Comput Biol. 2022 Oct 24;18(10):e1010633. doi: 10.1371/journal.pcbi.1010633. eCollection 2022 Oct. PLoS Comput Biol. 2022. PMID: 36279274 Free PMC article.
399 results