Fiorillo A - Search Results

1

Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis.

Exertier C, Salerno A, Antonelli L, Fiorillo A, Ocello R, Seghetti F, Caciolla J, Uliassi E, Masetti M, Fiorentino E, Orsini S, Di Muccio T, Ilari A, Bolognesi ML. Exertier C, et al. Among authors: fiorillo a. J Med Chem. 2024 Jan 11;67(1):402-419. doi: 10.1021/acs.jmedchem.3c01439. Epub 2024 Jan 2. J Med Chem. 2024. PMID: 38164929 Free PMC article.

2

The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.

Ilari A, Bonamore A, Franceschini S, Fiorillo A, Boffi A, Colotti G. Ilari A, et al. Among authors: fiorillo a. Proteins. 2008 Jun;71(4):2065-75. doi: 10.1002/prot.21898. Proteins. 2008. PMID: 18186483

3

Crystal structure of a family 16 endoglucanase from the hyperthermophile Pyrococcus furiosus--structural basis of substrate recognition.

Ilari A, Fiorillo A, Angelaccio S, Florio R, Chiaraluce R, van der Oost J, Consalvi V. Ilari A, et al. Among authors: fiorillo a. FEBS J. 2009 Feb;276(4):1048-58. doi: 10.1111/j.1742-4658.2008.06848.x. Epub 2008 Jan 16. FEBS J. 2009. PMID: 19154353 Free article.

4

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.

Ilari A, Baiocco P, Messori L, Fiorillo A, Boffi A, Gramiccia M, Di Muccio T, Colotti G. Ilari A, et al. Among authors: fiorillo a. Amino Acids. 2012 Feb;42(2-3):803-11. doi: 10.1007/s00726-011-0997-9. Epub 2011 Aug 11. Amino Acids. 2012. PMID: 21833767 Free PMC article.

5

The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway.

Fiorillo A, Colotti G, Boffi A, Baiocco P, Ilari A. Fiorillo A, et al. PLoS Negl Trop Dis. 2012;6(8):e1781. doi: 10.1371/journal.pntd.0001781. Epub 2012 Aug 21. PLoS Negl Trop Dis. 2012. PMID: 22928053 Free PMC article.

6

Kineococcus radiotolerans Dps forms a heteronuclear Mn-Fe ferroxidase center that may explain the Mn-dependent protection against oxidative stress.

Ardini M, Fiorillo A, Fittipaldi M, Stefanini S, Gatteschi D, Ilari A, Chiancone E. Ardini M, et al. Among authors: fiorillo a. Biochim Biophys Acta. 2013 Jun;1830(6):3745-55. doi: 10.1016/j.bbagen.2013.02.003. Epub 2013 Feb 8. Biochim Biophys Acta. 2013. PMID: 23396000

7

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.

Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Baiocco P, et al. Among authors: fiorillo a. ChemMedChem. 2013 Jul;8(7):1175-83. doi: 10.1002/cmdc.201300176. Epub 2013 Jun 3. ChemMedChem. 2013. PMID: 23733388

8

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.

Colotti G, Ilari A, Fiorillo A, Baiocco P, Cinellu MA, Maiore L, Scaletti F, Gabbiani C, Messori L. Colotti G, et al. Among authors: fiorillo a. ChemMedChem. 2013 Oct;8(10):1634-7. doi: 10.1002/cmdc.201300276. Epub 2013 Aug 23. ChemMedChem. 2013. PMID: 24039168

9

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.

Colotti G, Baiocco P, Fiorillo A, Boffi A, Poser E, Chiaro FD, Ilari A. Colotti G, et al. Among authors: fiorillo a. Future Med Chem. 2013 Oct;5(15):1861-75. doi: 10.4155/fmc.13.146. Future Med Chem. 2013. PMID: 24144416 Review.

10

The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference.

Fiorillo A, di Marino D, Bertuccini L, Via A, Pozio E, Camerini S, Ilari A, Lalle M. Fiorillo A, et al. PLoS One. 2014 Mar 21;9(3):e92902. doi: 10.1371/journal.pone.0092902. eCollection 2014. PLoS One. 2014. PMID: 24658679 Free PMC article.

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