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Impaired suppression of fatty acid release by insulin is a strong predictor of reduced whole-body insulin-mediated glucose uptake and skeletal muscle insulin receptor activation.
Schleh MW, Ryan BJ, Ahn C, Ludzki AC, Van Pelt DW, Pitchford LM, Chugh OK, Luker AT, Luker KE, Samovski D, Abumrad NA, Burant CF, Horowitz JF. Schleh MW, et al. Among authors: ludzki ac. Acta Physiol (Oxf). 2025 Jan;241(1):e14249. doi: 10.1111/apha.14249. Epub 2024 Nov 1. Acta Physiol (Oxf). 2025. PMID: 39487600 Free PMC article.
Transcriptional determinants of lipid mobilization in human adipocytes.
Ludzki AC, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, Renzi G, Klingelhuber F, Boland S, Ambaw YA, Wang N, Damdimopoulos A, Liu J, Jernberg T, Petrus P, Arner P, Krahmer N, Fan R, Treuter E, Gao H, Rydén M, Mejhert N. Ludzki AC, et al. Sci Adv. 2024 Jan 5;10(1):eadi2689. doi: 10.1126/sciadv.adi2689. Epub 2024 Jan 3. Sci Adv. 2024. PMID: 38170777 Free PMC article.
Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity.
Schleh MW, Ahn C, Ryan BJ, Chugh OK, Luker AT, Luker KE, Gillen JB, Ludzki AC, Van Pelt DW, Pitchford LM, Zhang T, Rode T, Howton SM, Burant CF, Horowitz JF. Schleh MW, et al. Among authors: ludzki ac. Am J Physiol Endocrinol Metab. 2023 Nov 1;325(5):E466-E479. doi: 10.1152/ajpendo.00093.2023. Epub 2023 Sep 20. Am J Physiol Endocrinol Metab. 2023. PMID: 37729021 Free PMC article.
Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin.
Schleh MW, Ryan BJ, Ahn C, Ludzki AC, Varshney P, Gillen JB, Van Pelt DW, Pitchford LM, Howton SM, Rode T, Chenevert TL, Hummel SL, Burant CF, Horowitz JF. Schleh MW, et al. Among authors: ludzki ac. Obesity (Silver Spring). 2023 May;31(5):1347-1361. doi: 10.1002/oby.23734. Epub 2023 Mar 29. Obesity (Silver Spring). 2023. PMID: 36988872 Free PMC article.
13 results