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VB-111 (ofranergene obadenovec) in combination with nivolumab in patients with microsatellite stable colorectal liver metastases: a single center, single arm, phase II trial.
Coffman-D'Annibale K, Myojin Y, Monge C, Xie C, Hrones DM, Wood BJ, Levy EB, Kleiner D, Figg WD, Steinberg SM, Redd B, Greten TF. Coffman-D'Annibale K, et al. Among authors: kleiner d. J Immunother Cancer. 2024 Jan 6;12(1):e008079. doi: 10.1136/jitc-2023-008079. J Immunother Cancer. 2024. PMID: 38184304 Free PMC article. Clinical Trial.
Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy.
Budhu A, Pehrsson EC, He A, Goyal L, Kelley RK, Dang H, Xie C, Monge C, Tandon M, Ma L, Revsine M, Kuhlman L, Zhang K, Baiev I, Lamm R, Patel K, Kleiner DE, Hewitt SM, Tran B, Shetty J, Wu X, Zhao Y, Shen TW, Choudhari S, Kriga Y, Ylaya K, Warner AC, Edmondson EF, Forgues M, Greten TF, Wang XW. Budhu A, et al. Cell Rep Med. 2023 Jun 20;4(6):101052. doi: 10.1016/j.xcrm.2023.101052. Epub 2023 May 23. Cell Rep Med. 2023. PMID: 37224815 Free PMC article.
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin.
Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Murphy Soika DQ, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF. Ruf B, et al. Among authors: kleiner de. Cell. 2023 Aug 17;186(17):3686-3705.e32. doi: 10.1016/j.cell.2023.07.026. Cell. 2023. PMID: 37595566 Free PMC article.
Non-selective dampening of the host immune response after hepatitis C clearance and its association with circulating chemokine and endotoxin levels.
Quinn G, Ali RO, Zhang GY, Hill K, Townsend E, Umarova R, Chakraborty M, Ahmad MF, Gewirtz M, Haddad J, Rosenzweig S, Rampertaap S, Schoenfeld M, Yang S, Koh C, Levy E, Kleiner DE, Etzion O, Heller T. Quinn G, et al. Liver Int. 2023 Dec;43(12):2701-2712. doi: 10.1111/liv.15737. Epub 2023 Sep 26. Liver Int. 2023. PMID: 37752797
Development of mouse models with restricted HLA-B∗57:01 presentation for the study of flucloxacillin-driven T-cell activation and tolerance in liver injury.
Ananthula S, Krishnaveni Sivakumar K, Cardone M, Su S, Roderiquez G, Abuzeineh H, Kleiner DE, Norcross MA, Puig M. Ananthula S, et al. J Allergy Clin Immunol. 2023 Aug;152(2):486-499.e7. doi: 10.1016/j.jaci.2023.03.029. Epub 2023 Apr 7. J Allergy Clin Immunol. 2023. PMID: 37030592 Free PMC article.
Proteomic Analysis of Hepatic Fibrosis in Human Immunodeficiency Virus-Associated Nonalcoholic Fatty Liver Disease Demonstrates Up-regulation of Immune Response and Tissue Repair Pathways.
Fourman LT, Stanley TL, Ockene MW, McClure CM, Toribio M, Corey KE, Chung RT, Torriani M, Kleiner DE, Hadigan CM, Grinspoon SK. Fourman LT, et al. J Infect Dis. 2023 Feb 14;227(4):565-576. doi: 10.1093/infdis/jiac475. J Infect Dis. 2023. PMID: 36461941 Free PMC article.
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