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Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
Borsuk R, Zhou L, Chang WI, Zhang Y, Sharma A, Prabhu VV, Tapinos N, Lulla RR, El-Deiry WS. Borsuk R, et al. Among authors: sharma a. Am J Cancer Res. 2021 Sep 15;11(9):4607-4623. eCollection 2021. Am J Cancer Res. 2021. PMID: 34659909 Free PMC article.
Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma.
Sharma A, Nair R, Achreja A, Mittal A, Gupta P, Balakrishnan K, Edgar CL, Animasahun O, Dwivedi B, Barwick BG, Gupta VA, Matulis SM, Bhasin M, Lonial S, Nooka AK, Wiita AP, Boise LH, Nagrath D, Shanmugam M. Sharma A, et al. Sci Adv. 2022 Sep 30;8(39):eabq5575. doi: 10.1126/sciadv.abq5575. Epub 2022 Sep 28. Sci Adv. 2022. PMID: 36170375 Free PMC article.
PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.
Funk CR, Wang S, Chen KZ, Waller A, Sharma A, Edgar CL, Gupta VA, Chandrakasan S, Zoine JT, Fedanov A, Raikar SS, Koff JL, Flowers CR, Coma S, Pachter JA, Ravindranathan S, Spencer HT, Shanmugam M, Waller EK. Funk CR, et al. Among authors: sharma a. Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597. Blood. 2022. PMID: 35084470 Free PMC article.
Chemoradiotherapy Induced Hearing Impairment in Head and Neck Malignancies.
Jangir JK, Agarwal S, Singhal P, Gupta N, Raj M, Verma S, Sharma AK, Jat KS, Nirwan S. Jangir JK, et al. Among authors: sharma ak. Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5353-5358. doi: 10.1007/s12070-024-04975-3. Epub 2024 Sep 2. Indian J Otolaryngol Head Neck Surg. 2024. PMID: 39559070
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