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Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma.
Hamel AR, Yan W, Rouhana JM, Monovarfeshani A, Jiang X, Mehta PA, Advani J, Luo Y, Liang Q, Rajasundaram S, Shrivastava A, Duchinski K, Mantena S, Wang J, van Zyl T, Pasquale LR, Swaroop A, Gharahkhani P, Khawaja AP, MacGregor S; International Glaucoma Genetics Consortium (IGGC); Chen R, Vitart V, Sanes JR, Wiggs JL, Segrè AV. Hamel AR, et al. Among authors: luo y. Nat Commun. 2024 Jan 9;15(1):396. doi: 10.1038/s41467-023-44380-y. Nat Commun. 2024. PMID: 38195602 Free PMC article.
Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study.
Singh RK, Zhao Y, Elze T, Fingert J, Gordon M, Kass MA, Luo Y, Pasquale LR, Scheetz T, Segrè AV, Wiggs JL, Zebardast N. Singh RK, et al. Among authors: luo y. medRxiv [Preprint]. 2023 Aug 16:2023.08.15.23294141. doi: 10.1101/2023.08.15.23294141. medRxiv. 2023. Update in: JAMA Ophthalmol. 2024 Apr 1;142(4):356-363. doi: 10.1001/jamaophthalmol.2024.0151 PMID: 37645858 Free PMC article. Updated. Preprint.
Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record-Linked Biobanks.
Tran JH, Kang J, Han E, Gupta U, Seresirikachorn K, Vy HMT, Zhao Y, Rocheleau G, Luo Y, Lee R, Do R, Friedman DS, Kang JH, Wiggs JL, Pasquale LR, Segrè AV, Zebardast N. Tran JH, et al. Among authors: luo y. Am J Ophthalmol. 2024 Nov;267:204-212. doi: 10.1016/j.ajo.2024.06.007. Epub 2024 Jun 19. Am J Ophthalmol. 2024. PMID: 38906208
The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts.
de Vries VA, Hanyuda A, Vergroesen JE, Do R, Friedman DS, Kraft P, Turman C, Luo YL, Tran JH, Liefers B, Wong SH, Lee RH, Zebardast N, Klaver CCW, Segrè AV, Pasquale LR, Wiggs JL, Kang JH, Ramdas WD. de Vries VA, et al. Ophthalmology. 2024 Aug 14:S0161-6420(24)00464-0. doi: 10.1016/j.ophtha.2024.08.005. Online ahead of print. Ophthalmology. 2024. PMID: 39128550 Free article.
Structure-based network analysis predicts mutations associated with inherited retinal disease.
Hauser BM, Luo Y, Nathan A, Gaiha GD, Vavvas D, Comander J, Pierce EA, Place EM, Bujakowska KM, Rossin EJ. Hauser BM, et al. Among authors: luo y. medRxiv [Preprint]. 2023 Jul 6:2023.07.05.23292247. doi: 10.1101/2023.07.05.23292247. medRxiv. 2023. Update in: NPJ Genom Med. 2024 May 27;9(1):31. doi: 10.1038/s41525-024-00416-w PMID: 37461650 Free PMC article. Updated. Preprint.
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