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Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.
Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.
A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.
Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K. Wensien M, et al. Among authors: funk lm. Nature. 2021 May;593(7859):460-464. doi: 10.1038/s41586-021-03513-3. Epub 2021 May 5. Nature. 2021. PMID: 33953398
Widespread occurrence of covalent lysine-cysteine redox switches in proteins.
Rabe von Pappenheim F, Wensien M, Ye J, Uranga J, Irisarri I, de Vries J, Funk LM, Mata RA, Tittmann K. Rabe von Pappenheim F, et al. Among authors: funk lm. Nat Chem Biol. 2022 Apr;18(4):368-375. doi: 10.1038/s41589-021-00966-5. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165445 Free PMC article.
Low-barrier hydrogen bonds in enzyme cooperativity.
Dai S, Funk LM, von Pappenheim FR, Sautner V, Paulikat M, Schröder B, Uranga J, Mata RA, Tittmann K. Dai S, et al. Among authors: funk lm. Nature. 2019 Sep;573(7775):609-613. doi: 10.1038/s41586-019-1581-9. Epub 2019 Sep 18. Nature. 2019. PMID: 31534226
19F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of E. coli Ribonucleotide Reductase.
Meyer A, Kehl A, Cui C, Reichardt FAK, Hecker F, Funk LM, Ghosh MK, Pan KT, Urlaub H, Tittmann K, Stubbe J, Bennati M. Meyer A, et al. Among authors: funk lm. J Am Chem Soc. 2022 Jun 29;144(25):11270-11282. doi: 10.1021/jacs.2c02906. Epub 2022 Jun 2. J Am Chem Soc. 2022. PMID: 35652913 Free PMC article.
U.S. weight trends: a longitudinal analysis of an NIH-partnered dataset.
Jawara D, Krebsbach CM, Venkatesh M, Murtha JA, Hanlon BM, Lauer KV, Stalter LN, Funk LM. Jawara D, et al. Among authors: funk lm. Int J Obes (Lond). 2024 Oct 29. doi: 10.1038/s41366-024-01661-w. Online ahead of print. Int J Obes (Lond). 2024. PMID: 39472690
135 results