Tittmann K - Search Results

1

Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.

Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Among authors: tittmann k. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.

2

Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.

Bar-Ilan A, Balan V, Tittmann K, Golbik R, Vyazmensky M, Hübner G, Barak Z, Chipman DM. Bar-Ilan A, et al. Among authors: tittmann k. Biochemistry. 2001 Oct 2;40(39):11946-54. doi: 10.1021/bi0104524. Biochemistry. 2001. PMID: 11570896

3

Activation of thiamin diphosphate and FAD in the phosphatedependent pyruvate oxidase from Lactobacillus plantarum.

Tittmann K, Proske D, Spinka M, Ghisla S, Rudolph R, Hübner G, Kern G. Tittmann K, et al. J Biol Chem. 1998 May 22;273(21):12929-34. doi: 10.1074/jbc.273.21.12929. J Biol Chem. 1998. PMID: 9582325 Free article.

4

Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.

Vyazmensky M, Steinmetz A, Meyer D, Golbik R, Barak Z, Tittmann K, Chipman DM. Vyazmensky M, et al. Among authors: tittmann k. Biochemistry. 2011 Apr 19;50(15):3250-60. doi: 10.1021/bi102051h. Epub 2011 Mar 23. Biochemistry. 2011. PMID: 21370850

5

Mechanism of elementary catalytic steps of pyruvate oxidase from Lactobacillus plantarum.

Tittmann K, Golbik R, Ghisla S, Hübner G. Tittmann K, et al. Biochemistry. 2000 Sep 5;39(35):10747-54. doi: 10.1021/bi0004089. Biochemistry. 2000. PMID: 10978159

6

Activation of thiamine diphosphate in pyruvate decarboxylase from Zymomonas mobilis.

Tittmann K, Mesch K, Pohl M, Hübner G. Tittmann K, et al. FEBS Lett. 1998 Dec 28;441(3):404-6. doi: 10.1016/s0014-5793(98)01594-4. FEBS Lett. 1998. PMID: 9891980 Free article.

7

Studies on structure-function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway.

Schütz A, Golbik R, Tittmann K, Svergun DI, Koch MH, Hübner G, König S. Schütz A, et al. Among authors: tittmann k. Eur J Biochem. 2003 May;270(10):2322-31. doi: 10.1046/j.1432-1033.2003.03602.x. Eur J Biochem. 2003. PMID: 12752452 Free article.

8

The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR.

Tittmann K, Vyazmensky M, Hübner G, Barak Z, Chipman DM. Tittmann K, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):553-8. doi: 10.1073/pnas.0408210101. Epub 2005 Jan 7. Proc Natl Acad Sci U S A. 2005. PMID: 15640355 Free PMC article.

9

Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.

Tittmann K, Schröder K, Golbik R, McCourt J, Kaplun A, Duggleby RG, Barak Z, Chipman DM, Hübner G. Tittmann K, et al. Biochemistry. 2004 Jul 13;43(27):8652-61. doi: 10.1021/bi049897t. Biochemistry. 2004. PMID: 15236573

10

Activation of thiamin diphosphate in enzymes.

Hübner G, Tittmann K, Killenberg-Jabs M, Schäffner J, Spinka M, Neef H, Kern D, Kern G, Schneider G, Wikner C, Ghisla S. Hübner G, et al. Among authors: tittmann k. Biochim Biophys Acta. 1998 Jun 29;1385(2):221-8. doi: 10.1016/s0167-4838(98)00070-3. Biochim Biophys Acta. 1998. PMID: 9655909

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