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Page 1
Integrative proteomic analyses across common cardiac diseases yield new mechanistic insights and enhanced prediction.
Schuermans A, Pournamdari AB, Lee J, Bhukar R, Ganesh S, Darosa N, Small AM, Yu Z, Hornsby W, Koyama S, Januzzi JL, Honigberg MC, Natarajan P. Schuermans A, et al. Among authors: hornsby w. medRxiv [Preprint]. 2023 Dec 19:2023.12.19.23300218. doi: 10.1101/2023.12.19.23300218. medRxiv. 2023. Update in: Nat Cardiovasc Res. 2024 Dec;3(12):1516-1530. doi: 10.1038/s44161-024-00567-0 PMID: 38196601 Free PMC article. Updated. Preprint.
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, Dikilitas O, Pattee JW, Judy RL, Pauls-Verges F, Nielsen JB, Wolford BN, Brumpton BM, Dilmé J, Peypoch O, Juscafresa LC, Edwards TL, Li D, Banasik K, Brunak S, Jacobsen RL, Garcia-Barrio MT, Zhang J, Rasmussen LM, Lee R, Handa A, Wanhainen A, Mani K, Lindholt JS, Obel LM, Strauss E, Oszkinis G, Nelson CP, Saxby KL, van Herwaarden JA, van der Laan SW, van Setten J, Camacho M, Davis FM, Wasikowski R, Tsoi LC, Gudjonsson JE, Eliason JL, Coleman DM, Henke PK, Ganesh SK, Chen YE, Guan W, Pankow JS, Pankratz N, Pedersen OB, Erikstrup C, Tang W, Hveem K, Gudbjartsson D, Gretarsdottir S, Thorsteinsdottir U, Holm H, Stefansson K, Ferreira MA, Baras A, Kullo IJ, Ritchie MD, Christensen AH, Iversen KK, Eldrup N, Sillesen H, Ostrowski SR, Bundgaard H, Ullum H, Burgess S, Gill D, Gallagher K, Sabater-Lleal M; DiscovEHR; Regeneron Genetics Center; UK Aneurysm Growth Study; DBDS Genomic Consortium; VA Million Veteran Program; Surakka I, Jones GT, Bown MJ, Tsao PS, Willer CJ, Damrauer SM. Roychowdhury T, et al. Among authors: hornsby we. Nat Genet. 2023 Nov;55(11):1831-1842. doi: 10.1038/s41588-023-01510-y. Epub 2023 Oct 16. Nat Genet. 2023. PMID: 37845353 Free PMC article.
Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study.
Douville NJ, Bastarache L, He J, Wu KH, Vanderwerff B, Bertucci-Richter E, Hornsby WE, Lewis A, Jewell ES, Kheterpal S, Shah N, Mathis M, Engoren MC, Douville CB, Surakka I, Willer C, Kertai MD. Douville NJ, et al. Among authors: hornsby we. Anesthesiology. 2025 Jan 1;142(1):52-71. doi: 10.1097/ALN.0000000000005214. Anesthesiology. 2025. PMID: 39250560 Free PMC article.
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.
Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, O… See abstract for full author list ➔ Zhou W, et al. Among authors: hornsby we. Cell Genom. 2022 Oct 12;2(10):100192. doi: 10.1016/j.xgen.2022.100192. eCollection 2022 Oct 12. Cell Genom. 2022. PMID: 36777996 Free PMC article.
The HUNT study: A population-based cohort for genetic research.
Brumpton BM, Graham S, Surakka I, Skogholt AH, Løset M, Fritsche LG, Wolford B, Zhou W, Nielsen JB, Holmen OL, Gabrielsen ME, Thomas L, Bhatta L, Rasheed H, Zhang H, Kang HM, Hornsby W, Moksnes MR, Coward E, Melbye M, Giskeødegård GF, Fenstad J, Krokstad S, Næss M, Langhammer A, Boehnke M, Abecasis GR, Åsvold BO, Hveem K, Willer CJ. Brumpton BM, et al. Among authors: hornsby w. Cell Genom. 2022 Oct 12;2(10):100193. doi: 10.1016/j.xgen.2022.100193. eCollection 2022 Oct 12. Cell Genom. 2022. PMID: 36777998 Free PMC article.
Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries.
Surakka I, Wu KH, Hornsby W, Wolford BN, Shen F, Zhou W, Huffman JE, Pandit A, Hu Y, Brumpton B, Skogholt AH, Gabrielsen ME, Walters RG; TOPMed Stroke Working Group; Million Veteran Program (MVP); Hveem K, Kooperberg C, Zöllner S, Wilson PWF, Sutton NR, Daly MJ, Neale BM, Willer CJ; Global Biobank Meta-analysis Initiative (GBMI). Surakka I, et al. Among authors: hornsby w. Cell Genom. 2023 Jun 19;3(8):100345. doi: 10.1016/j.xgen.2023.100345. eCollection 2023 Aug 9. Cell Genom. 2023. PMID: 37601974 Free PMC article.
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.
Wang Y, Namba S, Lopera E, Kerminen S, Tsuo K, Läll K, Kanai M, Zhou W, Wu KH, Favé MJ, Bhatta L, Awadalla P, Brumpton B, Deelen P, Hveem K, Lo Faro V, Mägi R, Murakami Y, Sanna S, Smoller JW, Uzunovic J, Wolford BN; Global Biobank Meta-analysis Initiative; Willer C, Gamazon ER, Cox NJ, Surakka I, Okada Y, Martin AR, Hirbo J. Wang Y, et al. Cell Genom. 2023 Jan 4;3(1):100241. doi: 10.1016/j.xgen.2022.100241. eCollection 2023 Jan 11. Cell Genom. 2023. PMID: 36777179 Free PMC article.
Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases.
Truong B, Hull LE, Ruan Y, Huang QQ, Hornsby W, Martin H, van Heel DA, Wang Y, Martin AR, Lee SH, Natarajan P. Truong B, et al. Among authors: hornsby w. medRxiv [Preprint]. 2023 Mar 23:2023.02.21.23286110. doi: 10.1101/2023.02.21.23286110. medRxiv. 2023. Update in: Cell Genom. 2024 Apr 10;4(4):100523. doi: 10.1016/j.xgen.2024.100523 PMID: 36865265 Free PMC article. Updated. Preprint.
Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease.
Gumuser ED, Schuermans A, Cho SMJ, Sporn ZA, Uddin MM, Paruchuri K, Nakao T, Yu Z, Haidermota S, Hornsby W, Weeks LD, Niroula A, Jaiswal S, Libby P, Ebert BL, Bick AG, Natarajan P, Honigberg MC. Gumuser ED, et al. Among authors: hornsby w. J Am Coll Cardiol. 2023 May 23;81(20):1996-2009. doi: 10.1016/j.jacc.2023.03.401. J Am Coll Cardiol. 2023. PMID: 37197843 Free PMC article.
Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.
Schuermans A, Nakao T, Ruan Y, Koyama S, Yu Z, Uddin MM, Haidermota S, Hornsby W, Lewandowski AJ, Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC. Schuermans A, et al. Among authors: hornsby w. J Am Heart Assoc. 2023 Jul 4;12(13):e030220. doi: 10.1161/JAHA.123.030220. Epub 2023 Jun 22. J Am Heart Assoc. 2023. PMID: 37345823 Free PMC article.
130 results