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Page 1
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.
Maas-Bauer K, Stell AV, Yan KL, de Vega E, Vinnakota JM, Unger S, Núñez N, Norona J, Talvard-Balland N, Koßmann S, Schwan C, Miething C, Martens US, Shoumariyeh K, Nestor RP, Duquesne S, Hanke K, Rackiewicz M, Hu Z, El Khawanky N, Taromi S, Andrlova H, Faraidun H, Walter S, Pfeifer D, Follo M, Waldschmidt J, Melchinger W, Rassner M, Wehr C, Schmitt-Graeff A, Halbach S, Liao J, Häcker G, Brummer T, Dengjel J, Andrieux G, Grosse R, Tugues S, Blazar BR, Becher B, Boerries M, Zeiser R. Maas-Bauer K, et al. Among authors: tugues s. Nat Commun. 2024 Jan 10;15(1):446. doi: 10.1038/s41467-024-44703-7. Nat Commun. 2024. PMID: 38199985 Free PMC article.
Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice.
Krishnarajah S, Ingelfinger F, Friebel E, Cansever D, Amorim A, Andreadou M, Bamert D, Litscher G, Lutz M, Mayoux M, Mundt S, Ridder F, Sparano C, Stifter SA, Ulutekin C, Unger S, Vermeer M, Zwicky P, Greter M, Tugues S, De Feo D, Becher B. Krishnarajah S, et al. Among authors: tugues s. Nat Aging. 2022 Jan;2(1):74-89. doi: 10.1038/s43587-021-00148-x. Epub 2021 Dec 16. Nat Aging. 2022. PMID: 37118354
Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells.
Sparano C, Solís-Sayago D, Zangger NS, Rindlisbacher L, Van Hove H, Vermeer M, Westermann F, Mussak C, Rallo E, Dergun S, Litscher G, Xu Y, Bijnen M, Friedrich C, Greter M, Juranić Lisnić V, Becher B, Gasteiger G, Oxenius A, Tugues S. Sparano C, et al. Among authors: tugues s. J Exp Med. 2025 Mar 3;222(3):e20240930. doi: 10.1084/jem.20240930. Epub 2024 Dec 18. J Exp Med. 2025. PMID: 39692745
IL-23 stabilizes an effector Treg cell program in the tumor microenvironment.
Wertheimer T, Zwicky P, Rindlisbacher L, Sparano C, Vermeer M, de Melo BMS, Haftmann C, Rückert T, Sethi A, Schärli S, Huber A, Ingelfinger F, Xu C, Kim D, Häne P, Fonseca da Silva A, Muschaweckh A, Nunez N, Krishnarajah S, Köhler N, Zeiser R, Oukka M, Korn T, Tugues S, Becher B. Wertheimer T, et al. Among authors: tugues s. Nat Immunol. 2024 Mar;25(3):512-524. doi: 10.1038/s41590-024-01755-7. Epub 2024 Feb 14. Nat Immunol. 2024. PMID: 38356059 Free PMC article.
CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice.
Bosch AJT, Keller L, Steiger L, Rohm TV, Wiedemann SJ, Low AJY, Stawiski M, Rachid L, Roux J, Konrad D, Wueest S, Tugues S, Greter M, Böni-Schnetzler M, Meier DT, Cavelti-Weder C. Bosch AJT, et al. Among authors: tugues s. Diabetologia. 2023 Dec;66(12):2292-2306. doi: 10.1007/s00125-023-06007-1. Epub 2023 Oct 4. Diabetologia. 2023. PMID: 37792013 Free PMC article.
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis.
Marinović S, Lenartić M, Mladenić K, Šestan M, Kavazović I, Benić A, Krapić M, Rindlisbacher L, Cokarić Brdovčak M, Sparano C, Litscher G, Turk Wensveen T, Mikolašević I, Fučkar Čupić D, Bilić-Zulle L, Steinle A, Waisman A, Hayday A, Tugues S, Becher B, Polić B, Wensveen FM. Marinović S, et al. Among authors: tugues s. Sci Immunol. 2023 Sep 29;8(87):eadd1599. doi: 10.1126/sciimmunol.add1599. Epub 2023 Sep 29. Sci Immunol. 2023. PMID: 37774007 Free PMC article.
Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation.
Ingelfinger F, Sparano C, Bamert D, Reyes-Leiva D, Sethi A, Rindlisbacher L, Zwicky P, Kreutmair S, Widmer CC, Mundt S, Cortés-Vicente E, Tugues S, Becher B, Schreiner B. Ingelfinger F, et al. Among authors: tugues s. J Allergy Clin Immunol. 2023 Jan;151(1):280-286.e2. doi: 10.1016/j.jaci.2022.09.010. Epub 2022 Sep 16. J Allergy Clin Immunol. 2023. PMID: 36122787 Free article.
Embryonic and neonatal waves generate distinct populations of hepatic ILC1s.
Sparano C, Solís-Sayago D, Vijaykumar A, Rickenbach C, Vermeer M, Ingelfinger F, Litscher G, Fonseca A, Mussak C, Mayoux M, Friedrich C, Nombela-Arrieta C, Gasteiger G, Becher B, Tugues S. Sparano C, et al. Among authors: tugues s. Sci Immunol. 2022 Sep 2;7(75):eabo6641. doi: 10.1126/sciimmunol.abo6641. Epub 2022 Sep 2. Sci Immunol. 2022. PMID: 36054340
IFN-λ: paving the road toward tissue protection in GVHD.
Wertheimer T, Tugues S. Wertheimer T, et al. Among authors: tugues s. Blood. 2021 Aug 26;138(8):596-597. doi: 10.1182/blood.2021012348. Blood. 2021. PMID: 34436528 Free article. No abstract available.
Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
Ducimetière L, Lucchiari G, Litscher G, Nater M, Heeb L, Nuñez NG, Wyss L, Burri D, Vermeer M, Gschwend J, Moor AE, Becher B, van den Broek M, Tugues S. Ducimetière L, et al. Among authors: tugues s. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2026271118. doi: 10.1073/pnas.2026271118. Proc Natl Acad Sci U S A. 2021. PMID: 34183415 Free PMC article.
46 results