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Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection.
Gallardo-Macias R, Russo R, Sherwood M, Jaskowski M, Nasser W, Sharma P, Tuckman M, Singleton E, Ho HP, Park S, Patel JS, George A, Perlin D, Zimmerman MD, Connell N, Freundlich JS. Gallardo-Macias R, et al. Among authors: perlin d. J Med Chem. 2024 Jan 25;67(2):1384-1392. doi: 10.1021/acs.jmedchem.3c01846. Epub 2024 Jan 15. J Med Chem. 2024. PMID: 38225186
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Shurtleff VW, Layton ME, Parish CA, Perkins JJ, Schreier JD, Wang Y, Adam GC, Alvarez N, Bahmanjah S, Bahnck-Teets CM, Boyce CW, Burlein C, Cabalu TD, Campbell BT, Carroll SS, Chang W, de Lera Ruiz M, Dolgov E, Fay JF, Fox NG, Goh SL, Hartingh TJ, Hurzy DM, Kelly MJ 3rd, Klein DJ, Klingler FM, Krishnamurthy H, Kudalkar S, Mayhood TW, McKenna PM, Murray EM, Nahas D, Nawrat CC, Park S, Qian D, Roecker AJ, Sharma V, Shipe WD, Su J, Taggart RV, Truong Q, Wu Y, Zhou X, Zhuang N, Perlin DS, Olsen DB, Howe JA, McCauley JA. Shurtleff VW, et al. Among authors: perlin ds. J Med Chem. 2024 Mar 14;67(5):3935-3958. doi: 10.1021/acs.jmedchem.3c02248. Epub 2024 Feb 16. J Med Chem. 2024. PMID: 38365209
In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19.
Mane V, Mehta R, Alvarez N, Sharma V, Park S, Fox A, DeCarlo C, Yang X, Perlin DS, Powell RLR. Mane V, et al. bioRxiv [Preprint]. 2023 Aug 28:2023.08.25.554813. doi: 10.1101/2023.08.25.554813. bioRxiv. 2023. Update in: Hum Vaccin Immunother. 2024 Dec 31;20(1):2303226. doi: 10.1080/21645515.2024.2303226 PMID: 37693438 Free PMC article. Updated. Preprint.
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.
Meyer C, Garzia A, Miller MW, Huggins DJ, Myers RW, Hoffmann HH, Ashbrook AW, Jannath SY, Liverton N, Kargman S, Zimmerman M, Nelson AM, Sharma V, Dolgov E, Cangialosi J, Penalva-Lopez S, Alvarez N, Chang CW, Oswal N, Gonzalez I, Rasheed R, Goldgirsh K, Davis JA, Ramos-Espiritu L, Menezes MR, Larson C, Nitsche J, Ganichkin O, Alwaseem H, Molina H, Steinbacher S, Glickman JF, Perlin DS, Rice CM, Meinke PT, Tuschl T. Meyer C, et al. Among authors: perlin ds. Nature. 2024 Dec 11. doi: 10.1038/s41586-024-08320-0. Online ahead of print. Nature. 2024. PMID: 39663451
Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.
Hassoun Y, Aptekmann AA, Keniya MV, Gomez RY, Alayo N, Novi G, Quinteros C, Kaya F, Zimmerman M, Caceres DH, Chow NA, Perlin DS, Shor E. Hassoun Y, et al. Among authors: perlin ds. PLoS Pathog. 2024 Sep 9;20(9):e1012521. doi: 10.1371/journal.ppat.1012521. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39250486 Free PMC article.
Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.
Alvarez N, Adam GC, Howe JA, Sharma V, Zimmerman MD, Dolgov E, Rasheed R, Nizar F, Sahay K, Nelson AM, Park S, Zhou X, Burlein C, Fay JF, Iwamoto DV, Bahnck-Teets CM, Getty KL, Lin Goh S, Salhab I, Smith K, Boyce CW, Cabalu TD, Murgolo N, Fox NG, Mayhood TW, Shurtleff VW, Layton ME, Parish CA, McCauley JA, Olsen DB, Perlin DS. Alvarez N, et al. Among authors: perlin ds. Viruses. 2024 Jul 18;16(7):1158. doi: 10.3390/v16071158. Viruses. 2024. PMID: 39066320 Free PMC article.
404 results