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Page 1
A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.
Papa A, Del Rivero Morfin PJ, Chen BX, Yang L, Katchman AN, Zakharov SI, Liu G, Bohnen MS, Zheng V, Katz M, Subramaniam S, Hirsch JA, Weiss S, Dascal N, Karlin A, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO. Papa A, et al. Among authors: zakharov si. J Clin Invest. 2024 Jan 16;134(5):e176943. doi: 10.1172/JCI176943. J Clin Invest. 2024. PMID: 38227371 Free PMC article.
Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response.
Papa A, Zakharov SI, Katchman AN, Kushner JS, Chen BX, Yang L, Liu G, Jimenez AS, Eisert RJ, Bradshaw GA, Dun W, Ali SR, Rodriques A, Zhou K, Topkara V, Yang M, Morrow JP, Tsai EJ, Karlin A, Wan E, Kalocsay M, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO. Papa A, et al. Among authors: zakharov si. Nat Cardiovasc Res. 2022 Nov;1(11):1022-1038. doi: 10.1038/s44161-022-00157-y. Epub 2022 Nov 14. Nat Cardiovasc Res. 2022. PMID: 36424916 Free PMC article.
Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery.
Wang BZ, Nash TR, Zhang X, Rao J, Abriola L, Kim Y, Zakharov S, Kim M, Luo LJ, Morsink M, Liu B, Lock RI, Fleischer S, Tamargo MA, Bohnen M, Welch CL, Chung WK, Marx SO, Surovtseva YV, Vunjak-Novakovic G, Fine BM. Wang BZ, et al. Cell Rep Med. 2023 Mar 21;4(3):100976. doi: 10.1016/j.xcrm.2023.100976. Epub 2023 Mar 14. Cell Rep Med. 2023. PMID: 36921598 Free PMC article.
Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current.
Katchman AN, Zakharov SI, Bohnen MS, Sanchez Jimenez A, Kushner JS, Yang L, Chen BX, Nasari A, Liu G, Rabbani DE, Han J, Leu CS, Pitt GS, Marx SO. Katchman AN, et al. Among authors: zakharov si. Circulation. 2024 May 14;149(20):1617-1620. doi: 10.1161/CIRCULATIONAHA.123.067298. Epub 2024 May 13. Circulation. 2024. PMID: 38739694 No abstract available.
Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.
Papa A, Kushner J, Hennessey JA, Katchman AN, Zakharov SI, Chen BX, Yang L, Lu R, Leong S, Diaz J, Liu G, Roybal D, Liao X, Del Rivero Morfin PJ, Colecraft HM, Pitt GS, Clarke O, Topkara V, Ben-Johny M, Marx SO. Papa A, et al. Among authors: zakharov si. Circ Res. 2021 Jan 8;128(1):76-88. doi: 10.1161/CIRCRESAHA.120.317839. Epub 2020 Oct 22. Circ Res. 2021. PMID: 33086983 Free PMC article.
Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
Abrams J, Roybal D, Chakouri N, Katchman AN, Weinberg R, Yang L, Chen BX, Zakharov SI, Hennessey JA, Avula UMR, Diaz J, Wang C, Wan EY, Pitt GS, Ben-Johny M, Marx SO. Abrams J, et al. Among authors: zakharov si. JCI Insight. 2020 Oct 2;5(19):e141736. doi: 10.1172/jci.insight.141736. JCI Insight. 2020. PMID: 32870823 Free PMC article.
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics.
Liu G, Papa A, Katchman AN, Zakharov SI, Roybal D, Hennessey JA, Kushner J, Yang L, Chen BX, Kushnir A, Dangas K, Gygi SP, Pitt GS, Colecraft HM, Ben-Johny M, Kalocsay M, Marx SO. Liu G, et al. Among authors: zakharov si. Nature. 2020 Jan;577(7792):695-700. doi: 10.1038/s41586-020-1947-z. Epub 2020 Jan 22. Nature. 2020. PMID: 31969708 Free PMC article.
Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice.
Wan E, Abrams J, Weinberg RL, Katchman AN, Bayne J, Zakharov SI, Yang L, Morrow JP, Garan H, Marx SO. Wan E, et al. Among authors: zakharov si. J Clin Invest. 2016 Jan;126(1):112-22. doi: 10.1172/JCI84669. Epub 2015 Nov 23. J Clin Invest. 2016. PMID: 26595809 Free PMC article.
71 results