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Page 1
Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M. Nagase H, et al. Among authors: kutsumura n. J Med Chem. 2017 Feb 9;60(3):1018-1040. doi: 10.1021/acs.jmedchem.6b01418. Epub 2017 Jan 18. J Med Chem. 2017. PMID: 28051300
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Saitoh T, et al. Among authors: kutsumura n. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2655-2658. doi: 10.1016/j.bmcl.2019.07.039. Epub 2019 Jul 24. Bioorg Med Chem Lett. 2019. PMID: 31375290
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Yanagisawa M, Nagase H. Saitoh T, et al. Among authors: kutsumura n. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126893. doi: 10.1016/j.bmcl.2019.126893. Epub 2019 Dec 17. Bioorg Med Chem Lett. 2020. PMID: 31879208
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Yamamoto N, et al. Among authors: kutsumura n. Bioorg Med Chem. 2019 Apr 15;27(8):1747-1758. doi: 10.1016/j.bmc.2019.03.010. Epub 2019 Mar 5. Bioorg Med Chem. 2019. PMID: 30871861
32 results