Hevel JM - Search Results

1

Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV-2 2'-O-Methyltransferase.

Hanna GS, Benjamin MM, Choo YM, De R, Schinazi RF, Nielson SE, Hevel JM, Hamann MT. Hanna GS, et al. Among authors: hevel jm. J Nat Prod. 2024 Feb 23;87(2):217-227. doi: 10.1021/acs.jnatprod.3c00875. Epub 2024 Jan 19. J Nat Prod. 2024. PMID: 38242544

2

Oligomerization of protein arginine methyltransferase 1 and its effect on methyltransferase activity and substrate specificity.

Rossi V, Nielson SE, Ortolano A, Lonardo I, Haroldsen E, Comer D, Price OM, Wallace N, Hevel JM. Rossi V, et al. Among authors: hevel jm. Protein Sci. 2024 Aug;33(8):e5118. doi: 10.1002/pro.5118. Protein Sci. 2024. PMID: 39022984 Free PMC article.

3

Substrate-induced control of product formation by protein arginine methyltransferase 1.

Gui S, Wooderchak-Donahue WL, Zang T, Chen D, Daly MP, Zhou ZS, Hevel JM. Gui S, et al. Among authors: hevel jm. Biochemistry. 2013 Jan 8;52(1):199-209. doi: 10.1021/bi301283t. Epub 2012 Dec 21. Biochemistry. 2013. PMID: 23214442

4

Examining Product Specificity in Protein Arginine Methyltransferase 7 (PRMT7) Using Quantum and Molecular Mechanical Simulations.

Thakur A, Hevel JM, Acevedo O. Thakur A, et al. Among authors: hevel jm. J Chem Inf Model. 2019 Jun 24;59(6):2913-2923. doi: 10.1021/acs.jcim.9b00137. Epub 2019 May 7. J Chem Inf Model. 2019. PMID: 31033288

5

A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine.

Gui S, Gathiaka S, Li J, Qu J, Acevedo O, Hevel JM. Gui S, et al. Among authors: hevel jm. J Biol Chem. 2014 Mar 28;289(13):9320-7. doi: 10.1074/jbc.M113.535278. Epub 2014 Jan 29. J Biol Chem. 2014. PMID: 24478314 Free PMC article.

6

Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics.

Gathiaka S, Boykin B, Cáceres T, Hevel JM, Acevedo O. Gathiaka S, et al. Among authors: hevel jm. Bioorg Med Chem. 2016 Oct 15;24(20):4949-4960. doi: 10.1016/j.bmc.2016.08.009. Epub 2016 Aug 6. Bioorg Med Chem. 2016. PMID: 27545444

7

Rapid and direct measurement of methyltransferase activity in about 30 min.

Hevel JM, Price OM. Hevel JM, et al. Methods. 2020 Mar 15;175:3-9. doi: 10.1016/j.ymeth.2019.10.002. Epub 2019 Oct 9. Methods. 2020. PMID: 31605745 Review.

8

A fast and efficient method for quantitative measurement of S-adenosyl-L-methionine-dependent methyltransferase activity with protein substrates.

Suh-Lailam BB, Hevel JM. Suh-Lailam BB, et al. Among authors: hevel jm. Anal Biochem. 2010 Mar 15;398(2):218-24. doi: 10.1016/j.ab.2009.09.005. Epub 2009 Sep 11. Anal Biochem. 2010. PMID: 19748473

9

Efficient cleavage of problematic tobacco etch virus (TEV)-protein arginine methyltransferase constructs.

Suh-Lailam BB, Hevel JM. Suh-Lailam BB, et al. Among authors: hevel jm. Anal Biochem. 2009 Apr 1;387(1):130-2. doi: 10.1016/j.ab.2008.12.031. Epub 2009 Jan 4. Anal Biochem. 2009. PMID: 19167339

10

Toward Understanding Molecular Recognition between PRMTs and their Substrates.

Price OM, Hevel JM. Price OM, et al. Among authors: hevel jm. Curr Protein Pept Sci. 2020;21(7):713-724. doi: 10.2174/1389203721666200124143145. Curr Protein Pept Sci. 2020. PMID: 31976831 Review.

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