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The (±)-5-Aza[1.0]triblattane Skeleton via Azetine Cycloaddition.
Su C, Dallaston MA, Watson RD, Fahrenhorst-Jones T, Cameron JP, Pierens GK, Bernhardt PV, Savage GP, Williams CM. Su C, et al. Among authors: savage gp. Org Lett. 2024 Apr 12;26(14):2827-2831. doi: 10.1021/acs.orglett.3c03655. Epub 2024 Jan 22. Org Lett. 2024. PMID: 38253345
Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.
Chalmers BA, Xing H, Houston S, Clark C, Ghassabian S, Kuo A, Cao B, Reitsma A, Murray CE, Stok JE, Boyle GM, Pierce CJ, Littler SW, Winkler DA, Bernhardt PV, Pasay C, De Voss JJ, McCarthy J, Parsons PG, Walter GH, Smith MT, Cooper HM, Nilsson SK, Tsanaktsidis J, Savage GP, Williams CM. Chalmers BA, et al. Among authors: savage gp. Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3580-5. doi: 10.1002/anie.201510675. Epub 2016 Feb 5. Angew Chem Int Ed Engl. 2016. PMID: 26846616
Cyclooctatetraene: A Bioactive Cubane Paradigm Complement.
Xing H, Houston SD, Chen X, Ghassabian S, Fahrenhorst-Jones T, Kuo A, Murray CP, Conn KA, Jaeschke KN, Jin DY, Pasay C, Bernhardt PV, Burns JM, Tsanaktsidis J, Savage GP, Boyle GM, De Voss JJ, McCarthy J, Walter GH, Burne THJ, Smith MT, Tie JK, Williams CM. Xing H, et al. Among authors: savage gp. Chemistry. 2019 Feb 21;25(11):2729-2734. doi: 10.1002/chem.201806277. Epub 2019 Jan 25. Chemistry. 2019. PMID: 30681236 Free PMC article.
Determining the necessity of phenyl ring π-character in warfarin.
Xing H, Houston SD, Chen X, Jin DY, Savage GP, Tie JK, Williams CM. Xing H, et al. Among authors: savage gp. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1954-1956. doi: 10.1016/j.bmcl.2019.05.039. Epub 2019 May 23. Bioorg Med Chem Lett. 2019. PMID: 31147103 Free PMC article.
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement.
Houston SD, Fahrenhorst-Jones T, Xing H, Chalmers BA, Sykes ML, Stok JE, Farfan Soto C, Burns JM, Bernhardt PV, De Voss JJ, Boyle GM, Smith MT, Tsanaktsidis J, Savage GP, Avery VM, Williams CM. Houston SD, et al. Among authors: savage gp. Org Biomol Chem. 2019 Jul 17;17(28):6790-6798. doi: 10.1039/c9ob01238a. Org Biomol Chem. 2019. PMID: 31241113
84 results