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Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.
Wilkinson-Smith V, Scott M, Menys A, Wiklendt L, Marciani L, Atkinson D, Sansone S, Zdanaviciene A, Coupland C, Knowles CH, Dinning P, Taylor SA, Gowland P, Hoad CL, Corsetti M, Spiller RC. Wilkinson-Smith V, et al. Among authors: wiklendt l. Gut. 2024 Dec 10;74(1):35-44. doi: 10.1136/gutjnl-2024-332755. Gut. 2024. PMID: 39438126 Free article. Clinical Trial.
TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.
Rajasekhar P, Carbone SE, Johnston ST, Nowell CJ, Wiklendt L, Crampin EJ, She Y, DiCello JJ, Saito A, Sorensen L, Nguyen T, Lee KM, Hamilton JA, King SK, Eriksson EM, Spencer NJ, Gulbransen BD, Veldhuis NA, Poole DP. Rajasekhar P, et al. Among authors: wiklendt l. bioRxiv [Preprint]. 2024 Jan 11:2024.01.09.574831. doi: 10.1101/2024.01.09.574831. bioRxiv. 2024. PMID: 38260314 Free PMC article. Preprint.
Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome.
Wiklendt L, Mohd Rosli R, Kumar R, Paskaranandavadivel N, Bampton PA, Maslen L, Costa M, Brookes SJ, O'Grady G, Dinning PG. Wiklendt L, et al. Am J Physiol Gastrointest Liver Physiol. 2023 Jul 1;325(1):G62-G79. doi: 10.1152/ajpgi.00114.2022. Epub 2023 May 10. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37162180 Free article.
Impact of exercise duration on gastrointestinal function and symptoms.
Gaskell SK, Burgell R, Wiklendt L, Dinning PG, Costa RJS. Gaskell SK, et al. Among authors: wiklendt l. J Appl Physiol (1985). 2023 Jan 1;134(1):160-171. doi: 10.1152/japplphysiol.00393.2022. Epub 2022 Dec 8. J Appl Physiol (1985). 2023. PMID: 36476157 Free article. Clinical Trial.
Disengaging spinal afferent nerve communication with the brain in live mice.
Kyloh MA, Hibberd TJ, Castro J, Harrington AM, Travis L, Dodds KN, Wiklendt L, Brierley SM, Zagorodnyuk VP, Spencer NJ. Kyloh MA, et al. Among authors: wiklendt l. Commun Biol. 2022 Sep 14;5(1):915. doi: 10.1038/s42003-022-03876-x. Commun Biol. 2022. PMID: 36104503 Free PMC article.
62 results