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523 results

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Page 1
Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
Tyhonas JS, Arnold LD, Cox JM, Franovic A, Gardiner E, Grandinetti K, Kania R, Kanouni T, Lardy M, Li C, Martin ES, Miller N, Mohan A, Murphy EA, Perez M, Soroceanu L, Timple N, Uryu S, Womble S, Kaldor SW. Tyhonas JS, et al. Among authors: murphy ea. J Med Chem. 2024 Feb 8;67(3):1734-1746. doi: 10.1021/acs.jmedchem.3c01819. Epub 2024 Jan 24. J Med Chem. 2024. PMID: 38267212
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Chen YK, Kanouni T, Arnold LD, Cox JM, Gardiner E, Grandinetti K, Jiang P, Kaldor SW, Lee C, Li C, Martin ES, Miller N, Murphy EA, Timple N, Tyhonas JS, Vassar A, Wang TS, Williams R, Yuan D, Kania RS. Chen YK, et al. Among authors: murphy ea. J Med Chem. 2024 Feb 8;67(3):1747-1757. doi: 10.1021/acs.jmedchem.3c01830. Epub 2024 Jan 17. J Med Chem. 2024. PMID: 38230963
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems.
Denoeud F, Godfroy O, Cruaud C, Heesch S, Nehr Z, Tadrent N, Couloux A, Brillet-Guéguen L, Delage L, Mckeown D, Motomura T, Sussfeld D, Fan X, Mazéas L, Terrapon N, Barrera-Redondo J, Petroll R, Reynes L, Choi SW, Jo J, Uthanumallian K, Bogaert K, Duc C, Ratchinski P, Lipinska A, Noel B, Murphy EA, Lohr M, Khatei A, Hamon-Giraud P, Vieira C, Avia K, Akerfors SS, Akita S, Badis Y, Barbeyron T, Belcour A, Berrabah W, Blanquart S, Bouguerba-Collin A, Bringloe T, Cattolico RA, Cormier A, Cruz de Carvalho H, Dallet R, De Clerck O, Debit A, Denis E, Destombe C, Dinatale E, Dittami S, Drula E, Faugeron S, Got J, Graf L, Groisillier A, Guillemin ML, Harms L, Hatchett WJ, Henrissat B, Hoarau G, Jollivet C, Jueterbock A, Kayal E, Knoll AH, Kogame K, Le Bars A, Leblanc C, Le Gall L, Ley R, Liu X, LoDuca ST, Lopez PJ, Lopez P, Manirakiza E, Massau K, Mauger S, Mest L, Michel G, Monteiro C, Nagasato C, Nègre D, Pelletier E, Phillips N, Potin P, Rensing SA, Rousselot E, Rousvoal S, Schroeder D, Scornet D, Siegel A, Tirichine L, Tonon T, Valentin K, Verbruggen H, Weinberger F, Wheeler G, Kawai H, Peters AF, Yoon HS, Hervé C, Ye N, Bapteste E, Valero M, Markov GV, Corre E, Coelho SM, Winck… See abstract for full author list ➔ Denoeud F, et al. Among authors: murphy ea. Cell. 2024 Nov 27;187(24):6943-6965.e39. doi: 10.1016/j.cell.2024.10.049. Epub 2024 Nov 20. Cell. 2024. PMID: 39571576 Free article.
Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10 -deficient mouse model.
Older EA, Mitchell MK, Campbell A, Lian X, Madden M, Wang Y, van de Wal LE, Zaw T, VanderVeen BN, Tatum R, Murphy EA, Chen YH, Fan D, Ellermann M, Li J. Older EA, et al. Among authors: murphy ea. bioRxiv [Preprint]. 2024 Oct 24:2024.10.23.619966. doi: 10.1101/2024.10.23.619966. bioRxiv. 2024. PMID: 39484420 Free PMC article. Preprint.
523 results