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Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
Rovito D, Rerra AI, Ueberschlag-Pitiot V, Joshi S, Karasu N, Dacleu-Siewe V, Rayana KB, Ghaibour K, Parisotto M, Ferry A, Jelinsky SA, Laverny G, Klaholz BP, Sexton T, Billas IML, Duteil D, Metzger D. Rovito D, et al. Among authors: sexton t. Nucleic Acids Res. 2021 May 7;49(8):4472-4492. doi: 10.1093/nar/gkab226. Nucleic Acids Res. 2021. PMID: 33836079 Free PMC article.
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus.
Taylor T, Sikorska N, Shchuka VM, Chahar S, Ji C, Macpherson NN, Moorthy SD, de Kort MAC, Mullany S, Khader N, Gillespie ZE, Langroudi L, Tobias IC, Lenstra TL, Mitchell JA, Sexton T. Taylor T, et al. Among authors: sexton t. Genes Dev. 2022 Jun 1;36(11-12):699-717. doi: 10.1101/gad.349489.122. Epub 2022 Jun 16. Genes Dev. 2022. PMID: 35710138 Free PMC article.
Short tandem repeats are important contributors to silencer elements in T cells.
Hussain S, Sadouni N, van Essen D, Dao LTM, Ferré Q, Charbonnier G, Torres M, Gallardo F, Lecellier CH, Sexton T, Saccani S, Spicuglia S. Hussain S, et al. Among authors: sexton t. Nucleic Acids Res. 2023 Jun 9;51(10):4845-4866. doi: 10.1093/nar/gkad187. Nucleic Acids Res. 2023. PMID: 36929452 Free PMC article.
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics.
Platania A, Erb C, Barbieri M, Molcrette B, Grandgirard E, de Kort MAC, Pomp W, Meaburn K, Taylor T, Shchuka VM, Kocanova S, Nazarova M, Oliveira GM, Mitchell JA, Soutoglou E, Lenstra TL, Molina N, Papantonis A, Bystricky K, Sexton T. Platania A, et al. Among authors: sexton t. Sci Adv. 2024 Dec 13;10(50):eadq0987. doi: 10.1126/sciadv.adq0987. Epub 2024 Dec 13. Sci Adv. 2024. PMID: 39671497 Free PMC article.
Competition between transcription and loop extrusion modulates promoter and enhancer dynamics.
Platania A, Erb C, Barbieri M, Molcrette B, Grandgirard E, de Kort MA, Meaburn K, Taylor T, Shchuka VM, Kocanova S, Oliveira GM, Mitchell JA, Soutoglou E, Lenstra TL, Molina N, Papantonis A, Bystricky K, Sexton T. Platania A, et al. Among authors: sexton t. bioRxiv [Preprint]. 2023 Apr 26:2023.04.25.538222. doi: 10.1101/2023.04.25.538222. bioRxiv. 2023. Update in: Sci Adv. 2024 Dec 13;10(50):eadq0987. doi: 10.1126/sciadv.adq0987 PMID: 37162887 Free PMC article. Updated. Preprint.
245 results