Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates.
Wang L, Hobson AD, Salomon PL, Fitzgibbons J, Xu J, McCarthy S, Wu K, Jia Y, Hernandez A Jr, Li X, Xu Z, Wang Z, Yu Y, Li J, Tao L.
Wang L, et al. Among authors: xu j, xu z.
RSC Med Chem. 2023 Nov 27;15(2):612-622. doi: 10.1039/d3md00569k. eCollection 2024 Feb 21.
RSC Med Chem. 2023.
PMID: 38389885
Free PMC article.