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Page 1
Alpha 1-acid glycoprotein is upregulated in severe COVID-19 patients and decreases neutrophil NETs in SARS-CoV-2 infection.
Mestriner F, Francisco DF, Campos LCB, Couto AES, Fraga-Silva TFC, Flora Dugaich V, D Avila-Mesquita C, Zukowski Kovacs H, Vasconcelos JL, Milani ER, Santos Guedes de Sá K, Martins R, Jordani MC, Corsi CAC, Barbosa JM, Vasconcelos T, Gonçalves Menegueti M, Neto J, da Costa RM, Evora PRB, Arruda E, Tostes R, Polonis K, Bonato VLD, Auxiliadora-Martins M, Ribeiro MS, Becari C. Mestriner F, et al. Among authors: bonato vld. Cytokine. 2024 Apr;176:156503. doi: 10.1016/j.cyto.2024.156503. Epub 2024 Jan 31. Cytokine. 2024. PMID: 38301358
Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients.
Potje SR, Costa TJ, Fraga-Silva TFC, Martins RB, Benatti MN, Almado CEL, de Sá KSG, Bonato VLD, Arruda E, Louzada-Junior P, Oliveira RDR, Zamboni DS, Becari C, Auxiliadora-Martins M, Tostes RC. Potje SR, et al. Among authors: bonato vld. Life Sci. 2021 Jul 1;276:119376. doi: 10.1016/j.lfs.2021.119376. Epub 2021 Mar 27. Life Sci. 2021. PMID: 33781826 Free PMC article.
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage.
Costa TJ, Potje SR, Fraga-Silva TFC, da Silva-Neto JA, Barros PR, Rodrigues D, Machado MR, Martins RB, Santos-Eichler RA, Benatti MN, de Sá KSG, Almado CEL, Castro ÍA, Pontelli MC, Serra L, Carneiro FS, Becari C, Louzada-Junior P, Oliveira RDR, Zamboni DS, Arruda E, Auxiliadora-Martins M, Giachini FRC, Bonato VLD, Zachara NE, Bomfim GF, Tostes RC. Costa TJ, et al. Among authors: bonato vld. Vascul Pharmacol. 2022 Feb;142:106946. doi: 10.1016/j.vph.2021.106946. Epub 2021 Nov 25. Vascul Pharmacol. 2022. PMID: 34838735 Free PMC article.
Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor.
Rodrigues D, Machado MR, Alves JV, Fraga-Silva TFC, Martins RB, Campos LCB, Francisco DF, Couto AES, Bonato VLD, Arruda E, Becari C, Auxiliadora-Martins M, Louzada-Júnior P, Costa RM, Tostes RC. Rodrigues D, et al. Among authors: bonato vld. Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H252-H263. doi: 10.1152/ajpheart.00096.2023. Epub 2023 Jun 16. Am J Physiol Heart Circ Physiol. 2023. PMID: 37327001 Free PMC article.
Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19.
Fraga-Silva TFC, Cipriano UG, Fumagalli MJ, Correa GF, Fuzo CA, Dos-Santos D, Mestriner FLAC, Becari C, Teixeira-Carvalho A, Coelho-Dos-Reis J, Menegueti MG, Figueiredo LTM, Cunha LD, Martins-Filho OA, Dias-Baruffi M, Auxiliadora-Martins M, Tostes RC, Bonato VLD. Fraga-Silva TFC, et al. Among authors: bonato vld. iScience. 2023 Oct 31;26(12):108366. doi: 10.1016/j.isci.2023.108366. eCollection 2023 Dec 15. iScience. 2023. PMID: 38047070 Free PMC article.
Celastrol: A lead compound that inhibits SARS-CoV-2 replication, the activity of viral and human cysteine proteases, and virus-induced IL-6 secretion.
Fuzo CA, Martins RB, Fraga-Silva TFC, Amstalden MK, Canassa De Leo T, Souza JP, Lima TM, Faccioli LH, Okamoto DN, Juliano MA, França SC, Juliano L, Bonato VLD, Arruda E, Dias-Baruffi M. Fuzo CA, et al. Among authors: bonato vld. Drug Dev Res. 2022 Nov;83(7):1623-1640. doi: 10.1002/ddr.21982. Epub 2022 Aug 21. Drug Dev Res. 2022. PMID: 35989498 Free PMC article.
NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model.
Carlos D, Pérez MM, Leite JA, Rocha FA, Martins LMS, Pereira CA, Fraga-Silva TFC, Pucci TA, Ramos SG, Câmara NOS, Bonato VLD, Tostes RC, Silva JS. Carlos D, et al. Among authors: bonato vld. Front Immunol. 2020 Jul 7;11:1265. doi: 10.3389/fimmu.2020.01265. eCollection 2020. Front Immunol. 2020. PMID: 32774333 Free PMC article.
Divergent androgenic modulation of SARS-CoV-2 infection cooperates with dysregulated immune response to dictate worse COVID-19 outcomes in men.
Duarte-Silva M, Oliveira CNS, Fuzo C, Silva-Neto PV, Toro DM, Pimentel VE, Pérez MM, Fraga-Silva TFC, Carvalho JCS, Neto FMS, Júnior RBM, Arruda E, Vilar FC, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, Gaspar GG, Rocha JJR, Feres O, Fernandes APM, Maruyama SR, Russo EMS, Bonato VLD, Santos IKFM, Sorgi CA, Dias-Baruffi M, Faccioli LH, Cardoso CRB; ImmunoCOVID Brazilian Research Consortium. Duarte-Silva M, et al. Among authors: bonato vld. Brain Behav Immun. 2023 Nov;114:275-286. doi: 10.1016/j.bbi.2023.08.026. Epub 2023 Aug 28. Brain Behav Immun. 2023. PMID: 37648004
Matrix Metalloproteinases on Severe COVID-19 Lung Disease Pathogenesis: Cooperative Actions of MMP-8/MMP-2 Axis on Immune Response through HLA-G Shedding and Oxidative Stress.
da Silva-Neto PV, do Valle VB, Fuzo CA, Fernandes TM, Toro DM, Fraga-Silva TFC, Basile PA, de Carvalho JCS, Pimentel VE, Pérez MM, Oliveira CNS, Rodrigues LC, Bastos VAF, Tella SOC, Martins RB, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, Vilar FC, Gaspar GG, Rocha JJRD, Feres O, Arruda E, Maruyama SR, Russo EMS, Viana AL, Santos IKFM, Bonato VLD, Cardoso CRB, Tanus-Santos JE, Donadi EA, Faccioli LH, Dias-Baruffi M, Fernandes APM, Gerlach RF, Sorgi CA, On Behalf Of The Immunocovid Study Group. da Silva-Neto PV, et al. Among authors: bonato vld. Biomolecules. 2022 Apr 19;12(5):604. doi: 10.3390/biom12050604. Biomolecules. 2022. PMID: 35625532 Free PMC article.
The effects of female sexual hormones on the endothelial glycocalyx.
Potje SR, Martins NS, Benatti MN, Rodrigues D, Bonato VLD, Tostes RC. Potje SR, et al. Among authors: bonato vld. Curr Top Membr. 2023;91:89-137. doi: 10.1016/bs.ctm.2023.02.005. Epub 2023 Mar 10. Curr Top Membr. 2023. PMID: 37080682 Review.
76 results