Lindahl E - Search Results

1

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids.

Haloi N, Huang S, Nichols AL, Fine EJ, Friesenhahn NJ, Marotta CB, Dougherty DA, Lindahl E, Howard RJ, Mayo SL, Lester HA. Haloi N, et al. Among authors: lindahl e. Protein Eng Des Sel. 2024 Jan 29;37:gzae003. doi: 10.1093/protein/gzae003. Protein Eng Des Sel. 2024. PMID: 38302088

2

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E. Murail S, et al. Among authors: lindahl e. PLoS Comput Biol. 2012;8(10):e1002710. doi: 10.1371/journal.pcbi.1002710. Epub 2012 Oct 4. PLoS Comput Biol. 2012. PMID: 23055913 Free PMC article.

3

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E. Brömstrup T, et al. Among authors: lindahl e. Structure. 2013 Aug 6;21(8):1307-16. doi: 10.1016/j.str.2013.06.018. Epub 2013 Jul 25. Structure. 2013. PMID: 23891290 Free PMC article.

4

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA. Heusser SA, et al. Among authors: lindahl e. Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692. Epub 2013 Aug 15. Mol Pharmacol. 2013. PMID: 23950219 Free PMC article.

5

Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.

Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ. Heusser SA, et al. Among authors: lindahl e. J Neurochem. 2016 Jul;138(2):243-53. doi: 10.1111/jnc.13644. Epub 2016 May 25. J Neurochem. 2016. PMID: 27102368 Free PMC article.

6

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.

Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Fourati Z, et al. Among authors: lindahl e. Cell Rep. 2018 Apr 24;23(4):993-1004. doi: 10.1016/j.celrep.2018.03.108. Cell Rep. 2018. PMID: 29694907 Free article.

7

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity.

Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Heusser SA, et al. Among authors: lindahl e. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10672-10677. doi: 10.1073/pnas.1809650115. Epub 2018 Oct 1. Proc Natl Acad Sci U S A. 2018. PMID: 30275330 Free PMC article.

8

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor.

Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM Jr, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Gharpure A, et al. Among authors: lindahl e. Neuron. 2019 Nov 6;104(3):501-511.e6. doi: 10.1016/j.neuron.2019.07.030. Epub 2019 Sep 2. Neuron. 2019. PMID: 31488329 Free PMC article.

9

Sharing Data from Molecular Simulations.

Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin AMJJ, Chavent M, Chodera J, Čondić-Jurkić K, Delemotte L, Grubmüller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A. Abraham M, et al. Among authors: lindahl e. J Chem Inf Model. 2019 Oct 28;59(10):4093-4099. doi: 10.1021/acs.jcim.9b00665. Epub 2019 Oct 11. J Chem Inf Model. 2019. PMID: 31525920

10

Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel.

Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Hu H, et al. Among authors: lindahl e. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13437-13446. doi: 10.1073/pnas.1922701117. Epub 2020 Jun 1. Proc Natl Acad Sci U S A. 2020. PMID: 32482881 Free PMC article.

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