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A phase 1 study of veliparib (ABT-888) plus weekly carboplatin and paclitaxel in advanced solid malignancies, with an expansion cohort in triple negative breast cancer (TNBC) (ETCTN 8620).
Malhotra MK, Pahuja S, Kiesel BF, Appleman LJ, Ding F, Lin Y, Tawbi HA, Stoller RG, Lee JJ, Belani CP, Chen AP, Giranda VL, Shepherd SP, Emens LA, Ivy SP, Chu E, Beumer JH, Puhalla S. Malhotra MK, et al. Among authors: beumer jh. Breast Cancer Res Treat. 2023 Apr;198(3):487-498. doi: 10.1007/s10549-023-06889-0. Epub 2023 Feb 28. Breast Cancer Res Treat. 2023. PMID: 36853577 Free PMC article. Clinical Trial.
Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal Emax regressions.
Beumer JH, Kennard BC, Holleran JL, Moore N, Zlott J, Miller BM, Kummar S, Chen A, Doroshow J, Park W, Gobburu J, Dunn A. Beumer JH, et al. Cancer Chemother Pharmacol. 2023 Mar;91(3):219-230. doi: 10.1007/s00280-023-04509-8. Epub 2023 Feb 23. Cancer Chemother Pharmacol. 2023. PMID: 36813886 Free PMC article.
Pharmacology and pharmacokinetics of elacestrant.
Beumer JH, Foldi J. Beumer JH, et al. Cancer Chemother Pharmacol. 2023 Aug;92(2):157-163. doi: 10.1007/s00280-023-04550-7. Epub 2023 Jun 14. Cancer Chemother Pharmacol. 2023. PMID: 37314500 Free PMC article.
Pharmacology and pharmacokinetics of tazemetostat.
Orleni M, Beumer JH. Orleni M, et al. Among authors: beumer jh. Cancer Chemother Pharmacol. 2024 May;93(5):509-517. doi: 10.1007/s00280-024-04658-4. Epub 2024 Mar 23. Cancer Chemother Pharmacol. 2024. PMID: 38520556 Review.
Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice.
Deppas JJ, Kiesel BF, Guo J, Parise RA, Clump DA, D'Argenio DZ, Bakkenist CJ, Beumer JH. Deppas JJ, et al. Among authors: beumer jh. Cancer Chemother Pharmacol. 2024 Aug;94(2):271-283. doi: 10.1007/s00280-024-04675-3. Epub 2024 May 14. Cancer Chemother Pharmacol. 2024. PMID: 38743253 Free PMC article.
200 results