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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
Yang X, Wang Z, Samovich SN, Kapralov AA, Amoscato AA, Tyurin VA, Dar HH, Li Z, Duan S, Kon N, Chen D, Tycko B, Zhang Z, Jiang X, Bayir H, Stockwell BR, Kagan VE, Gu W. Yang X, et al. Among authors: tycko b. Cell Metab. 2024 Apr 2;36(4):762-777.e9. doi: 10.1016/j.cmet.2024.01.006. Epub 2024 Feb 2. Cell Metab. 2024. PMID: 38309267 Free PMC article.
Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome.
Xing Z, Li Y, Cortes-Gomez E, Jiang X, Gao S, Pao A, Shan J, Song Y, Perez A, Yu T, Highsmith MR, Boadu F, Conroy JM, Singh PK, Bakin AV, Cheng J, Duan Z, Wang J, Liu S, Tycko B, Yu YE. Xing Z, et al. Among authors: tycko b. Hum Mol Genet. 2023 Jun 19;32(13):2205-2218. doi: 10.1093/hmg/ddad056. Hum Mol Genet. 2023. PMID: 37014740 Free PMC article.
R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription.
LaMarca EA, Saito A, Plaza-Jennings A, Espeso-Gil S, Hellmich A, Fernando MB, Javidfar B, Liao W, Estill M, Townsley K, Florio A, Ethridge JE, Do C, Tycko B, Shen L, Kamiya A, Tsankova NM, Brennand KJ, Akbarian S. LaMarca EA, et al. Among authors: tycko b. bioRxiv [Preprint]. 2023 Jul 18:2023.07.18.549494. doi: 10.1101/2023.07.18.549494. bioRxiv. 2023. PMID: 37503149 Free PMC article. Preprint.
Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Schworer EK, et al. Lancet Neurol. 2024 Dec;23(12):1214-1224. doi: 10.1016/S1474-4422(24)00426-5. Lancet Neurol. 2024. PMID: 39577922
The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome.
Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). Xicota L, et al. EBioMedicine. 2024 Dec;110:105433. doi: 10.1016/j.ebiom.2024.105433. Epub 2024 Nov 4. EBioMedicine. 2024. PMID: 39500037 Free PMC article.
Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome.
Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Aguilar LF, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock DM, Head E, Brickman AM. Edwards NC, et al. Brain Commun. 2024 Sep 25;6(5):fcae331. doi: 10.1093/braincomms/fcae331. eCollection 2024. Brain Commun. 2024. PMID: 39403075 Free PMC article.
193 results