Dotto GP - Search Results

1

ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.

Mazzeo L, Ghosh S, Di Cicco E, Isma J, Tavernari D, Samarkina A, Ostano P, Youssef MK, Simon C, Dotto GP. Mazzeo L, et al. Among authors: dotto gp. Nat Commun. 2024 Feb 3;15(1):1038. doi: 10.1038/s41467-024-45308-w. Nat Commun. 2024. PMID: 38310103 Free PMC article.

2

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.

Talora C, Sgroi DC, Crum CP, Dotto GP. Talora C, et al. Among authors: dotto gp. Genes Dev. 2002 Sep 1;16(17):2252-63. doi: 10.1101/gad.988902. Genes Dev. 2002. PMID: 12208848 Free PMC article.

3

Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression.

Grossi M, Hiou-Feige A, Tommasi Di Vignano A, Calautti E, Ostano P, Lee S, Chiorino G, Dotto GP. Grossi M, et al. Among authors: dotto gp. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11313-8. doi: 10.1073/pnas.0505011102. Epub 2005 Aug 1. Proc Natl Acad Sci U S A. 2005. PMID: 16061799 Free PMC article.

4

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.

Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP. Lefort K, et al. Among authors: dotto gp. Genes Dev. 2007 Mar 1;21(5):562-77. doi: 10.1101/gad.1484707. Genes Dev. 2007. PMID: 17344417 Free PMC article.

5

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.

Mandinova A, Lefort K, Tommasi di Vignano A, Stonely W, Ostano P, Chiorino G, Iwaki H, Nakanishi J, Dotto GP. Mandinova A, et al. Among authors: dotto gp. EMBO J. 2008 Apr 23;27(8):1243-54. doi: 10.1038/emboj.2008.45. Epub 2008 Apr 3. EMBO J. 2008. PMID: 18388864 Free PMC article.

6

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP. Kolev V, et al. Among authors: dotto gp. Nat Cell Biol. 2008 Aug;10(8):902-11. doi: 10.1038/ncb1750. Epub 2008 Jul 6. Nat Cell Biol. 2008. PMID: 18604200 Free PMC article.

7

A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.

Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Ostano P, Dummer R, Brissette JL, Dotto GP. Mandinova A, et al. Among authors: dotto gp. J Clin Invest. 2009 Oct;119(10):3127-37. doi: 10.1172/JCI38543. J Clin Invest. 2009. PMID: 19729838 Free PMC article.

8

Opposing roles for calcineurin and ATF3 in squamous skin cancer.

Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP. Wu X, et al. Among authors: dotto gp. Nature. 2010 May 20;465(7296):368-72. doi: 10.1038/nature08996. Nature. 2010. PMID: 20485437 Free PMC article.

9

Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.

Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP. Hu B, et al. Among authors: dotto gp. Cell. 2012 Jun 8;149(6):1207-20. doi: 10.1016/j.cell.2012.03.048. Cell. 2012. PMID: 22682244 Free PMC article.

10

A miR-34a-SIRT6 axis in the squamous cell differentiation network.

Lefort K, Brooks Y, Ostano P, Cario-André M, Calpini V, Guinea-Viniegra J, Albinger-Hegyi A, Hoetzenecker W, Kolfschoten I, Wagner EF, Werner S, Dotto GP. Lefort K, et al. Among authors: dotto gp. EMBO J. 2013 Aug 14;32(16):2248-63. doi: 10.1038/emboj.2013.156. Epub 2013 Jul 16. EMBO J. 2013. PMID: 23860128 Free PMC article.

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