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Page 1
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97.
Pozner A, Li L, Verma SP, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, John CM, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Mortenson KL, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. Pozner A, et al. Among authors: mortenson kl. Nat Commun. 2024 Feb 7;15(1):1165. doi: 10.1038/s41467-024-45280-5. Nat Commun. 2024. PMID: 38326311 Free PMC article.
A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer.
Liu Y, Wu Z, Zhou J, Ramadurai DKA, Mortenson KL, Aguilera-Jimenez E, Yan Y, Yang X, Taylor AM, Varley KE, Gertz J, Choi PS, Cherniack AD, Chen X, Bass AJ, Bailey SD, Zhang X. Liu Y, et al. Among authors: mortenson kl. Nat Commun. 2021 Dec 8;12(1):7139. doi: 10.1038/s41467-021-27055-4. Nat Commun. 2021. PMID: 34880227 Free PMC article.
Cis-regulatory control of transcriptional timing and noise in response to estrogen.
Ginley-Hidinger M, Abewe H, Osborne K, Richey A, Kitchen N, Mortenson KL, Wissink EM, Lis J, Zhang X, Gertz J. Ginley-Hidinger M, et al. Among authors: mortenson kl. bioRxiv [Preprint]. 2024 Feb 14:2023.03.14.532457. doi: 10.1101/2023.03.14.532457. bioRxiv. 2024. Update in: Cell Genom. 2024 May 8;4(5):100542. doi: 10.1016/j.xgen.2024.100542 PMID: 36993565 Free PMC article. Updated. Preprint.
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97.
Pozner A, Verma SP, Li L, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, Mortenson KL, John C, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. Pozner A, et al. Among authors: mortenson kl. bioRxiv [Preprint]. 2023 Oct 2:2023.09.29.560242. doi: 10.1101/2023.09.29.560242. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 7;15(1):1165. doi: 10.1038/s41467-024-45280-5 PMID: 37873234 Free PMC article. Updated. Preprint.
3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression.
Mortenson KL, Dawes C, Wilson ER, Patchen NE, Johnson HE, Gertz J, Bailey SD, Liu Y, Varley KE, Zhang X. Mortenson KL, et al. bioRxiv [Preprint]. 2024 Jun 21:2024.01.23.576965. doi: 10.1101/2024.01.23.576965. bioRxiv. 2024. Update in: Nat Commun. 2024 Jul 20;15(1):6130. doi: 10.1038/s41467-024-50387-w PMID: 38328209 Free PMC article. Updated. Preprint.
Cis-regulatory control of transcriptional timing and noise in response to estrogen.
Ginley-Hidinger M, Abewe H, Osborne K, Richey A, Kitchen N, Mortenson KL, Wissink EM, Lis J, Zhang X, Gertz J. Ginley-Hidinger M, et al. Among authors: mortenson kl. Cell Genom. 2024 May 8;4(5):100542. doi: 10.1016/j.xgen.2024.100542. Epub 2024 Apr 24. Cell Genom. 2024. PMID: 38663407 Free PMC article.
HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer.
Gnanapragasam A, Kirbizakis E, Li A, White KH, Mortenson KL, Cavalcante de Moura J, Jawhar W, Yan Y, Falter R, Russett C, Giannias B, Camilleri-Broët S, Bertos N, Cools-Lartigue J, Garzia L, Sangwan V, Ferri L, Zhang X, Bailey SD. Gnanapragasam A, et al. Among authors: mortenson kl. Cancer Res. 2024 Jul 15;84(14):2377-2389. doi: 10.1158/0008-5472.CAN-23-2397. Cancer Res. 2024. PMID: 38748784 Free PMC article.