Watt AP - Search Results

1

Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796.

Thornton P, Reader V, Digby Z, Smolak P, Lindsay N, Harrison D, Clarke N, Watt AP. Thornton P, et al. Among authors: watt ap. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826. doi: 10.1124/jpet.123.002013. J Pharmacol Exp Ther. 2024. PMID: 38336379

2

Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.

Harrison D, Billinton A, Bock MG, Doedens JR, Gabel CA, Holloway MK, Porter RA, Reader V, Scanlon J, Schooley K, Watt AP. Harrison D, et al. Among authors: watt ap. J Med Chem. 2023 Nov 9;66(21):14897-14911. doi: 10.1021/acs.jmedchem.3c01398. Epub 2023 Oct 24. J Med Chem. 2023. PMID: 37874905

3

Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency.

Smolak P, Nguyen M, Diamond C, Wescott H, Doedens JR, Schooley K, Snouwaert JN, Bock MG, Harrison D, Watt AP, Koller BH, Gabel CA. Smolak P, et al. Among authors: watt ap. J Pharmacol Exp Ther. 2024 Feb 15;388(3):798-812. doi: 10.1124/jpet.123.001941. J Pharmacol Exp Ther. 2024. PMID: 38253384

4

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

Doedens JR, Smolak P, Nguyen M, Wescott H, Diamond C, Schooley K, Billinton A, Harrison D, Koller BH, Watt AP, Gabel CA. Doedens JR, et al. Among authors: watt ap. ACS Pharmacol Transl Sci. 2024 Apr 18;7(5):1438-1456. doi: 10.1021/acsptsci.4c00061. eCollection 2024 May 10. ACS Pharmacol Transl Sci. 2024. PMID: 38751618

5

The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1.

Doedens JR, Diamond C, Harrison D, Bock MG, Clarke N, Watt AP, Gabel CA. Doedens JR, et al. Among authors: watt ap. Biochem Pharmacol. 2024 Sep;227:116455. doi: 10.1016/j.bcp.2024.116455. Epub 2024 Jul 26. Biochem Pharmacol. 2024. PMID: 39069136 Free article.

6

Endothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs.

Bell A, Watt AP, Dudink I, Pham Y, Sutherland AE, Allison BJ, McDonald CA, Castillo-Melendez M, Jenkin G, Malhotra A, Miller SL, Yawno T. Bell A, et al. Among authors: watt ap. Stem Cell Res Ther. 2023 Feb 14;14(1):29. doi: 10.1186/s13287-023-03249-z. Stem Cell Res Ther. 2023. PMID: 36788590 Free PMC article.

7

Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.

Harrison D, Bock MG, Doedens JR, Gabel CA, Holloway MK, Lewis A, Scanlon J, Sharpe A, Simpson ID, Smolak P, Wishart G, Watt AP. Harrison D, et al. Among authors: watt ap. ACS Med Chem Lett. 2022 Aug 1;13(8):1321-1328. doi: 10.1021/acsmedchemlett.2c00242. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978696 Free PMC article.

8

Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function.

Watt AP, Kirkland M, Nekkanti L, Pham Y, McDonald C, Malhotra A, Moeneclaey G, Miller SL, Jenkin G. Watt AP, et al. Cell Tissue Res. 2022 Apr;388(1):117-132. doi: 10.1007/s00441-022-03592-2. Epub 2022 Feb 2. Cell Tissue Res. 2022. PMID: 35106623 Free PMC article.

9

Insulin regulates human mammosphere development and function.

Watt AP, Lefevre C, Wong CS, Nicholas KR, Sharp JA. Watt AP, et al. Cell Tissue Res. 2021 May;384(2):333-352. doi: 10.1007/s00441-020-03360-0. Epub 2021 Jan 13. Cell Tissue Res. 2021. PMID: 33439347

10

Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers With Confirmed Coronavirus Disease 2019 (COVID-19).

Ladhani SN, Andrews N, Aiano F, Baawuah F, Amin-Chowdhury Z, Brown KE, Amirthalingam G, Ramsay ME, Waterfield T; RAPID-19 Investigation Team. Ladhani SN, et al. Clin Infect Dis. 2021 Jul 1;73(1):e260-e263. doi: 10.1093/cid/ciaa1737. Clin Infect Dis. 2021. PMID: 33201219 Free PMC article.

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