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Page 1
Impact of Linker Composition on VHL PROTAC Cell Permeability.
Abeje YE, Wieske LHE, Poongavanam V, Maassen S, Atilaw Y, Cromm P, Lehmann L, Erdelyi M, Meibom D, Kihlberg J. Abeje YE, et al. Among authors: meibom d. J Med Chem. 2025 Jan 9;68(1):638-657. doi: 10.1021/acs.jmedchem.4c02492. Epub 2024 Dec 18. J Med Chem. 2025. PMID: 39693386 Free PMC article.
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Meibom D, Wasnaire P, Beyer K, Broehl A, Cancho-Grande Y, Elowe N, Henninger K, Johannes S, Jungmann N, Krainz T, Lindner N, Maassen S, MacDonald B, Menshykau D, Mittendorf J, Sanchez G, Schaefer M, Stefan E, Torge A, Xing Y, Zubov D. Meibom D, et al. J Med Chem. 2024 Feb 22;67(4):2907-2940. doi: 10.1021/acs.jmedchem.3c02036. Epub 2024 Feb 13. J Med Chem. 2024. PMID: 38348661 Free PMC article.
Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
Roehrig S, Ackerstaff J, Jiménez Núñez E, Teller H, Ellerbrock P, Meier K, Heitmeier S, Tersteegen A, Stampfuss J, Lang D, Schlemmer KH, Schaefer M, Gericke KM, Kinzel T, Meibom D, Schmidt M, Gerdes C, Follmann M, Hillisch A. Roehrig S, et al. Among authors: meibom d. J Med Chem. 2023 Sep 14;66(17):12203-12224. doi: 10.1021/acs.jmedchem.3c00795. Epub 2023 Sep 5. J Med Chem. 2023. PMID: 37669040 Free PMC article.
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist.
Meibom D, Meyer J, von Buehler CJ, Collins KD, Maassen S, Gericke KM, Hüser J, Mittendorf J, Ortega Hernandez N, Schamberger J, Stampfuss J, Straub A, Torge A, Witowski N, Wunder F. Meibom D, et al. J Med Chem. 2023 Apr 13;66(7):4659-4670. doi: 10.1021/acs.jmedchem.2c01690. Epub 2023 Mar 18. J Med Chem. 2023. PMID: 36932954 Free PMC article.
Predictive Modeling of PROTAC Cell Permeability with Machine Learning.
Poongavanam V, Kölling F, Giese A, Göller AH, Lehmann L, Meibom D, Kihlberg J. Poongavanam V, et al. Among authors: meibom d. ACS Omega. 2023 Feb 1;8(6):5901-5916. doi: 10.1021/acsomega.2c07717. eCollection 2023 Feb 14. ACS Omega. 2023. PMID: 36816707 Free PMC article.
BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor.
Meibom D, Micus S, Andreevski AL, Anlauf S, Bogner P, von Buehler CJ, Dieskau AP, Dreher J, Eitner F, Fliegner D, Follmann M, Gericke KM, Maassen S, Meyer J, Schlemmer KH, Steuber H, Tersteegen A, Wunder F. Meibom D, et al. J Med Chem. 2022 Dec 22;65(24):16420-16431. doi: 10.1021/acs.jmedchem.2c01267. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475653 Free PMC article.
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability.
Poongavanam V, Atilaw Y, Siegel S, Giese A, Lehmann L, Meibom D, Erdelyi M, Kihlberg J. Poongavanam V, et al. Among authors: meibom d. J Med Chem. 2022 Oct 13;65(19):13029-13040. doi: 10.1021/acs.jmedchem.2c00877. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170570 Free PMC article.
Solution Conformations Shed Light on PROTAC Cell Permeability.
Atilaw Y, Poongavanam V, Svensson Nilsson C, Nguyen D, Giese A, Meibom D, Erdelyi M, Kihlberg J. Atilaw Y, et al. Among authors: meibom d. ACS Med Chem Lett. 2020 Dec 25;12(1):107-114. doi: 10.1021/acsmedchemlett.0c00556. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488971 Free PMC article.
Potent and Selective Human Prostaglandin F (FP) Receptor Antagonist (BAY-6672) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF).
Beck H, Thaler T, Meibom D, Meininghaus M, Jörißen H, Dietz L, Terjung C, Bairlein M, von Bühler CJ, Anlauf S, Fürstner C, Stellfeld T, Schneider D, Gericke KM, Buyck T, Lovis K, Münster U, Anlahr J, Kersten E, Levilain G, Marossek V, Kast R. Beck H, et al. Among authors: meibom d. J Med Chem. 2020 Oct 22;63(20):11639-11662. doi: 10.1021/acs.jmedchem.0c00834. Epub 2020 Oct 8. J Med Chem. 2020. PMID: 32969660
13 results