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Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.
Hegde S, Marriott AE, Pionnier N, Steven A, Bulman C, Gunderson E, Vogel I, Koschel M, Ehrens A, Lustigman S, Voronin D, Tricoche N, Hoerauf A, Hübner MP, Sakanari J, Aljayyoussi G, Gusovsky F, Dagley J, Hong DW, O'Neill P, Ward SA, Taylor MJ, Turner JD. Hegde S, et al. Among authors: gunderson e. Front Microbiol. 2024 Feb 1;15:1346068. doi: 10.3389/fmicb.2024.1346068. eCollection 2024. Front Microbiol. 2024. PMID: 38362501 Free PMC article.
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
Hübner MP, Gunderson E, Vogel I, Bulman CA, Lim KC, Koschel M, Ehrens A, Frohberger SJ, Fendler M, Tricoche N, Voronin D, Steven A, Chi V, Bakowski MA, Woods AK, Petrassi HM, McNamara CW, Beerntsen B, Chappell L, Sullivan W, Taylor MJ, Turner JD, Hoerauf A, Lustigman S, Sakanari JA. Hübner MP, et al. Among authors: gunderson e. Int J Parasitol Drugs Drug Resist. 2020 Apr;12:18-27. doi: 10.1016/j.ijpddr.2019.12.001. Epub 2019 Dec 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 31869759 Free PMC article.
The Eagle effect in the Wolbachia-worm symbiosis.
Bulman CA, Chappell L, Gunderson E, Vogel I, Beerntsen B, Slatko BE, Sullivan W, Sakanari JA. Bulman CA, et al. Among authors: gunderson e. Parasit Vectors. 2021 Feb 24;14(1):118. doi: 10.1186/s13071-020-04545-w. Parasit Vectors. 2021. PMID: 33627171 Free PMC article.
Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads.
Gunderson EL, Bryant C, Bulman CA, Fischer C, Luo M, Vogel I, Lim KC, Jawahar S, Tricoche N, Voronin D, Corbo C, Ayiseh RB, Manfo FPT, Mbah GE, Cho-Ngwa F, Beerntsen B, Renslo AR, Lustigman S, Sakanari JA. Gunderson EL, et al. Pharmaceuticals (Basel). 2022 Feb 2;15(2):189. doi: 10.3390/ph15020189. Pharmaceuticals (Basel). 2022. PMID: 35215301 Free PMC article.
The endosymbiont Wolbachia rebounds following antibiotic treatment.
Gunderson EL, Vogel I, Chappell L, Bulman CA, Lim KC, Luo M, Whitman JD, Franklin C, Choi YJ, Lefoulon E, Clark T, Beerntsen B, Slatko B, Mitreva M, Sullivan W, Sakanari JA. Gunderson EL, et al. PLoS Pathog. 2020 Jul 8;16(7):e1008623. doi: 10.1371/journal.ppat.1008623. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32639986 Free PMC article.
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation.
Garrido Ruiz D, Sandoval-Perez A, Rangarajan AV, Gunderson EL, Jacobson MP. Garrido Ruiz D, et al. Biochemistry. 2022 Oct 18;61(20):2165-2176. doi: 10.1021/acs.biochem.2c00349. Epub 2022 Sep 26. Biochemistry. 2022. PMID: 36161872 Free PMC article. Review.
413 results