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Pan-cancer Genomic Analysis of AXL Mutations Reveals a Novel, Recurrent, Functionally Activating AXL W451C Alteration Specific to Myxofibrosarcoma.
Williams EA, Vegas I, El-Senduny FF, Zhang J, Mata DA, Hiemenz MC, Hughes SR, Sa BC, Kraft GP, Gorbatov N, Foley-Peres K, Sanchez EZ, Milikowski C, Williams KJ, Ross JS, Kurzrock R, Montgomery EA, Lombard DB, Kumar S. Williams EA, et al. Among authors: lombard db. Am J Surg Pathol. 2024 Jun 1;48(6):699-707. doi: 10.1097/PAS.0000000000002191. Epub 2024 Feb 19. Am J Surg Pathol. 2024. PMID: 38369783 Free PMC article.
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress.
Melnick A, Liang S, Liu Y, Wang Q, Dean N, Choe E, Kunnath N, Bodanapu G, Mullin C, Akter F, Lin K, Magnuson B, Kumar S, Lombard DB, Muntean AG, Ljungman M, Sekiguchi J, Ryan RJH, Chiang MY. Melnick A, et al. Among authors: lombard db. bioRxiv [Preprint]. 2023 Feb 4:2023.01.22.525059. doi: 10.1101/2023.01.22.525059. bioRxiv. 2023. Update in: Blood. 2023 Dec 21;142(25):2159-2174. doi: 10.1182/blood.2023020144. PMID: 36711472 Free PMC article. Updated. Preprint.
Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer.
Zhang L, Troccoli CI, Mateo-Victoriano B, Misiara Lincheta L, Jackson E, Shu P, Plastini T, Tao W, Kwon D, Chen XS, Sharma J, Jorda M, Kumar S, Lombard DB, Gulley JL, Bilusic M, Lockhart AC, Beuve A, Rai P. Zhang L, et al. Among authors: lombard db. Cancer Res. 2024 Oct 10. doi: 10.1158/0008-5472.CAN-24-0133. Online ahead of print. Cancer Res. 2024. PMID: 39388307
Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.
Yuan T, Kumar S, Skinner ME, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: lombard db. iScience. 2024 May 15;27(6):109991. doi: 10.1016/j.isci.2024.109991. eCollection 2024 Jun 21. iScience. 2024. PMID: 38846003 Free PMC article.
SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology.
Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: lombard db. bioRxiv [Preprint]. 2023 Dec 8:2023.12.06.570371. doi: 10.1101/2023.12.06.570371. bioRxiv. 2023. PMID: 38105987 Free PMC article. Preprint.
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress.
Melnick AF, Mullin C, Lin K, McCarter AC, Liang S, Liu YE, Wang Q, Jerome NA, Choe E, Kunnath N, Bodanapu G, Akter F, Magnuson B, Kumar S, Lombard DB, Muntean AG, Ljungman M, Sekiguchi J, Ryan RJH, Chiang MY. Melnick AF, et al. Among authors: lombard db. Blood. 2023 Dec 21;142(25):2159-2174. doi: 10.1182/blood.2023020144. Blood. 2023. PMID: 37616559
93 results