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Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation.
Venkatasubramanian M, Schwartz L, Ramachandra N, Bennett J, Subramanian KR, Chen X, Gordon-Mitchell S, Fromowitz A, Pradhan K, Shechter D, Sahu S, Heiser D, Scherle P, Chetal K, Kulkarni A, Myers KC, Weirauch MT, Grimes HL, Starczynowski DT, Verma A, Salomonis N. Venkatasubramanian M, et al. bioRxiv [Preprint]. 2024 Feb 8:2024.02.04.578798. doi: 10.1101/2024.02.04.578798. bioRxiv. 2024. PMID: 38370617 Free PMC article. Preprint.
Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy.
Li G, Mahajan S, Ma S, Jeffery ED, Zhang X, Bhattacharjee A, Venkatasubramanian M, Weirauch MT, Miraldi ER, Grimes HL, Sheynkman GM, Tilburgs T, Salomonis N. Li G, et al. Among authors: venkatasubramanian m. Sci Transl Med. 2024 Jan 17;16(730):eade2886. doi: 10.1126/scitranslmed.ade2886. Epub 2024 Jan 17. Sci Transl Med. 2024. PMID: 38232136 Free PMC article.
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Itskovich SS, Gurunathan A, Clark J, Burwinkel M, Wunderlich M, Berger MR, Kulkarni A, Chetal K, Venkatasubramanian M, Salomonis N, Kumar AR, Lee LH. Itskovich SS, et al. Among authors: venkatasubramanian m. Nat Commun. 2020 May 12;11(1):2369. doi: 10.1038/s41467-020-15733-8. Nat Commun. 2020. PMID: 32398749 Free PMC article.
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.
Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Churko JM, et al. Among authors: venkatasubramanian m. Nat Commun. 2018 Nov 21;9(1):4906. doi: 10.1038/s41467-018-07333-4. Nat Commun. 2018. PMID: 30464173 Free PMC article.
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