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Page 1
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
Vendeville S, Amblard F, Bassit L, Beigelman LN, Blatt LM, Chen X, Chou L, Kum DB, Chanda S, Deval J, Geng X, Gupta K, Jekle A, Hu H, Hu X, Kang H, Liu C, Liu J, McGowan DC, Misner DL, Raboisson P, Sanchez AA, Serebryany V, Stoycheva AD, Symons JA, Tan H, Vanrusselt H, Williams C, Welch M, Zhang L, Zhang Q, Zhang Y, Schinazi RF, Smith DB, Debing Y. Vendeville S, et al. Among authors: debing y. J Med Chem. 2024 Dec 12;67(23):21126-21142. doi: 10.1021/acs.jmedchem.4c01814. Epub 2024 Nov 22. J Med Chem. 2024. PMID: 39575679
CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1.
Taverniti V, Meiss-Heydmann L, Gadenne C, Vanrusselt H, Kum DB, Giannone F, Pessaux P, Schuster C, Baumert TF, Debing Y, Verrier ER. Taverniti V, et al. Among authors: debing y. JHEP Rep. 2024 Jun 10;6(10):101134. doi: 10.1016/j.jhepr.2024.101134. eCollection 2024 Oct. JHEP Rep. 2024. PMID: 39386256 Free PMC article.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Debing Y, Vanrusselt H, Degrauwe L, Silva de Oliveira DA, Kariuki CK, Ebwanga EJ, Bashir S, Merckx W, Thatikonda SK, Rajwanshi V, Gohil V, Hong J, Kum DB, Acosta Sanchez A, Chanda S, Blatt LM, Jekle A, Symons JA, Smith DB, Raboisson P, Lin TI, Beigelman L, Paeshuyse J. Debing Y, et al. Antiviral Res. 2024 Apr;224:105835. doi: 10.1016/j.antiviral.2024.105835. Epub 2024 Feb 23. Antiviral Res. 2024. PMID: 38401714
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
Vanrusselt H, Kum DB, Taverniti V, Liu C, Acosta Sanchez A, Corthout N, Munck S, Baumert TF, Beigelman L, Blatt LM, Symons JA, Deval J, Raboisson P, Verrier ER, Jekle A, Vendeville S, Debing Y. Vanrusselt H, et al. Among authors: debing y. J Virol. 2023 Oct 31;97(10):e0072223. doi: 10.1128/jvi.00722-23. Epub 2023 Sep 27. J Virol. 2023. PMID: 37754761 Free PMC article.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Kum DB, Vanrusselt H, Acosta Sanchez A, Taverniti V, Verrier ER, Baumert TF, Liu C, Deval J, Corthout N, Munck S, Beigelman L, Blatt LM, Symons JA, Raboisson P, Jekle A, Vendeville S, Debing Y. Kum DB, et al. Among authors: debing y. Hepatology. 2023 Oct 1;78(4):1252-1265. doi: 10.1097/HEP.0000000000000428. Epub 2023 Apr 28. Hepatology. 2023. PMID: 37102495
Genome Sequences and Phylogeny of Two Duck Hepatitis B Viruses.
Apolônio Silva de Oliveira D, Debing Y, Dieryck I, Lyimu WM, Paeshuyse J. Apolônio Silva de Oliveira D, et al. Among authors: debing y. Microbiol Resour Announc. 2021 Feb 18;10(7):e01327-20. doi: 10.1128/MRA.01327-20. Microbiol Resour Announc. 2021. PMID: 33602732 Free PMC article.
Hepatitis E virus replication and interferon responses in human placental cells.
Knegendorf L, Drave SA, Dao Thi VL, Debing Y, Brown RJP, Vondran FWR, Resner K, Friesland M, Khera T, Engelmann M, Bremer B, Wedemeyer H, Behrendt P, Neyts J, Pietschmann T, Todt D, Steinmann E. Knegendorf L, et al. Among authors: debing y. Hepatol Commun. 2018 Jan 8;2(2):173-187. doi: 10.1002/hep4.1138. eCollection 2018 Feb. Hepatol Commun. 2018. PMID: 29404525 Free PMC article.
36 results