Levine PM - Search Results

1

Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants.

Liu S, Daley EJ, Tran LM, Yu Z, Reyes M, Dean T, Khatri A, Levine PM, Balana AT, Pratt MR, Jüppner H, Gellman SH, Gardella TJ. Liu S, et al. Among authors: levine pm. J Am Chem Soc. 2024 Mar 13;146(10):6522-6529. doi: 10.1021/jacs.3c09694. Epub 2024 Feb 28. J Am Chem Soc. 2024. PMID: 38417010

2

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.

Lewis YE, Galesic A, Levine PM, De Leon CA, Lamiri N, Brennan CK, Pratt MR. Lewis YE, et al. Among authors: levine pm. ACS Chem Biol. 2017 Apr 21;12(4):1020-1027. doi: 10.1021/acschembio.7b00113. Epub 2017 Feb 22. ACS Chem Biol. 2017. PMID: 28195695 Free PMC article.

3

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.

Levine PM, De Leon CA, Galesic A, Balana A, Marotta NP, Lewis YE, Pratt MR. Levine PM, et al. Bioorg Med Chem. 2017 Sep 15;25(18):4977-4982. doi: 10.1016/j.bmc.2017.04.038. Epub 2017 Apr 29. Bioorg Med Chem. 2017. PMID: 28487126 Free PMC article.

4

The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels.

De Leon CA, Levine PM, Craven TW, Pratt MR. De Leon CA, et al. Among authors: levine pm. Biochemistry. 2017 Jul 11;56(27):3507-3517. doi: 10.1021/acs.biochem.7b00268. Epub 2017 Jun 30. Biochemistry. 2017. PMID: 28627871 Free PMC article.

5

Revolutionizing Our Understanding of Amyloidogenic Proteins by Cryo-Electron Microscopy.

Levine PM, Pratt MR. Levine PM, et al. Biochemistry. 2018 Feb 13;57(6):895-896. doi: 10.1021/acs.biochem.7b01084. Epub 2018 Jan 11. Biochemistry. 2018. PMID: 29323876 No abstract available.

6

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.

Levine PM, Galesic A, Balana AT, Mahul-Mellier AL, Navarro MX, De Leon CA, Lashuel HA, Pratt MR. Levine PM, et al. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1511-1519. doi: 10.1073/pnas.1808845116. Epub 2019 Jan 16. Proc Natl Acad Sci U S A. 2019. PMID: 30651314 Free PMC article.

7

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.

Levine PM, Balana AT, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR. Levine PM, et al. J Am Chem Soc. 2019 Sep 11;141(36):14210-14219. doi: 10.1021/jacs.9b05365. Epub 2019 Aug 28. J Am Chem Soc. 2019. PMID: 31418572 Free PMC article.

8

O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity.

Balana AT, Levine PM, Craven TW, Mukherjee S, Pedowitz NJ, Moon SP, Takahashi TT, Becker CFW, Baker D, Pratt MR. Balana AT, et al. Among authors: levine pm. Nat Chem. 2021 May;13(5):441-450. doi: 10.1038/s41557-021-00648-8. Epub 2021 Mar 15. Nat Chem. 2021. PMID: 33723378 Free PMC article.

9

Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation".

Levine PM, Craven TW, Li X, Balana AT, Bird GH, Godes M, Salveson PJ, Erickson PW, Lamb M, Ahlrichs M, Murphy M, Ogohara C, Said MY, Walensky LD, Pratt MR, Baker D. Levine PM, et al. ACS Chem Biol. 2022 Apr 15;17(4):804-809. doi: 10.1021/acschembio.2c00075. Epub 2022 Mar 23. ACS Chem Biol. 2022. PMID: 35319882 Free PMC article.

10

Multivalent peptidomimetic conjugates: a versatile platform for modulating androgen receptor activity.

Levine PM, Imberg K, Garabedian MJ, Kirshenbaum K. Levine PM, et al. J Am Chem Soc. 2012 Apr 25;134(16):6912-5. doi: 10.1021/ja300170n. Epub 2012 Apr 17. J Am Chem Soc. 2012. PMID: 22509763

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