West AP - Search Results

1

3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data.

Hu L, De Hoyos D, Lei Y, West AP, Walsh AJ. Hu L, et al. Among authors: west ap. APL Bioeng. 2024 Feb 27;8(1):016112. doi: 10.1063/5.0188476. eCollection 2024 Mar. APL Bioeng. 2024. PMID: 38420625 Free PMC article.

2

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.

Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. Zhao B, et al. Among authors: west ap. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May 22. Nature. 2019. PMID: 31118511 Free PMC article.

3

Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G. Key J, et al. Among authors: west ap. Neurogenetics. 2020 Jul;21(3):187-203. doi: 10.1007/s10048-020-00609-2. Epub 2020 Apr 28. Neurogenetics. 2020. PMID: 32342250 Free PMC article.

4

The molecular basis of tight nuclear tethering and inactivation of cGAS.

Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P. Zhao B, et al. Among authors: west ap. Nature. 2020 Nov;587(7835):673-677. doi: 10.1038/s41586-020-2749-z. Epub 2020 Sep 10. Nature. 2020. PMID: 32911481 Free PMC article.

5

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.

Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP. Torres-Odio S, et al. Among authors: west ap. J Immunol. 2021 Apr 15;206(8):1890-1900. doi: 10.4049/jimmunol.2001016. Epub 2021 Mar 17. J Immunol. 2021. PMID: 33731338 Free PMC article.

6

Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.

Lei Y, Guerra Martinez C, Torres-Odio S, Bell SL, Birdwell CE, Bryant JD, Tong CW, Watson RO, West LC, West AP. Lei Y, et al. Among authors: west lc, west ap. Sci Adv. 2021 May 26;7(22):eabe7548. doi: 10.1126/sciadv.abe7548. Print 2021 May. Sci Adv. 2021. PMID: 34039599 Free PMC article.

7

Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons.

Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, West AP, Geoffroy CG. Sutherland TC, et al. Among authors: west ap. Cells. 2021 Jun 29;10(7):1625. doi: 10.3390/cells10071625. Cells. 2021. PMID: 34209640 Free PMC article.

8

Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.

Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP. Bryant JD, et al. Among authors: west ap. Curr Protoc. 2022 Feb;2(2):e372. doi: 10.1002/cpz1.372. Curr Protoc. 2022. PMID: 35175686 Free PMC article.

9

Inflammatory and interferon gene expression signatures in patients with mitochondrial disease.

Warren E, Gordon-Lipkin EM, Cheung F, Chen J, Mukherjee A, Apps R, Tsang JS, Jetmore J, Kruk S, Lei Y, West AP, McGuire PJ. Warren E, et al. Among authors: west ap. Res Sq [Preprint]. 2023 Feb 27:rs.3.rs-2612547. doi: 10.21203/rs.3.rs-2612547/v1. Res Sq. 2023. Update in: J Transl Med. 2023 May 19;21(1):331. doi: 10.1186/s12967-023-04180-w PMID: 36909538 Free PMC article. Updated. Preprint.

10

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.

Al Khatib I, Deng J, Lei Y, Torres-Odio S, Rojas GR, Newman LE, Chung BK, Symes A, Zhang H, Huang SN, Pommier Y, Khan A, Shadel GS, West AP, Gibson WT, Shutt TE. Al Khatib I, et al. Among authors: west ap. Hum Mol Genet. 2023 Jul 20;32(15):2422-2440. doi: 10.1093/hmg/ddad062. Hum Mol Genet. 2023. PMID: 37129502 Free PMC article.

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