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JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors.
Pennel KAF, Hatthakarnkul P, Wood CS, Lian GY, Al-Badran SSF, Quinn JA, Legrini A, Inthagard J, Alexander PG, van Wyk H, Kurniawan A, Hashmi U, Gillespie MA, Mills M, Ammar A, Hay J, Andersen D, Nixon C, Rebus S, Chang DK, Kelly C, Harkin A, Graham J, Church D, Tomlinson I, Saunders M, Iveson T, Lannagan TRM, Jackstadt R, Maka N, Horgan PG, Roxburgh CSD, Sansom OJ, McMillan DC, Steele CW, Jamieson NB, Park JH, Roseweir AK, Edwards J. Pennel KAF, et al. Among authors: chang dk. J Exp Clin Cancer Res. 2024 Mar 1;43(1):64. doi: 10.1186/s13046-024-02958-4. J Exp Clin Cancer Res. 2024. PMID: 38424636 Free PMC article.
Pancreatic cancer genomics: where can the science take us?
Graham JS, Jamieson NB, Rulach R, Grimmond SM, Chang DK, Biankin AV. Graham JS, et al. Among authors: chang dk. Clin Genet. 2015 Sep;88(3):213-9. doi: 10.1111/cge.12536. Epub 2015 Jan 19. Clin Genet. 2015. PMID: 25388820 Review.
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ. Miller BW, et al. EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827. EMBO Mol Med. 2015. PMID: 26077591 Free PMC article.
Defining the molecular pathology of pancreatic body and tail adenocarcinoma.
Dreyer SB, Jamieson NB, Upstill-Goddard R, Bailey PJ, McKay CJ; Australian Pancreatic Cancer Genome Initiative; Biankin AV, Chang DK. Dreyer SB, et al. Among authors: chang dk. Br J Surg. 2018 Jan;105(2):e183-e191. doi: 10.1002/bjs.10772. Br J Surg. 2018. PMID: 29341146 Free PMC article.
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF. Reader CS, et al. J Pathol. 2019 Nov;249(3):332-342. doi: 10.1002/path.5320. Epub 2019 Jul 30. J Pathol. 2019. PMID: 31259422 Free PMC article.
Pancreatic Cancer: From Genome Discovery to PRECISION-Panc.
Dreyer SB, Jamieson NB, Morton JP, Sansom OJ, Biankin AV, Chang DK. Dreyer SB, et al. Among authors: chang dk. Clin Oncol (R Coll Radiol). 2020 Jan;32(1):5-8. doi: 10.1016/j.clon.2019.08.007. Epub 2019 Sep 12. Clin Oncol (R Coll Radiol). 2020. PMID: 31522943 Free article. No abstract available.
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.
Dreyer SB, Upstill-Goddard R, Paulus-Hock V, Paris C, Lampraki EM, Dray E, Serrels B, Caligiuri G, Rebus S, Plenker D, Galluzzo Z, Brunton H, Cunningham R, Tesson M, Nourse C, Bailey UM, Jones M, Moran-Jones K, Wright DW, Duthie F, Oien K, Evers L, McKay CJ, McGregor GA, Gulati A, Brough R, Bajrami I, Pettitt S, Dziubinski ML, Candido J, Balkwill F, Barry ST, Grützmann R, Rahib L; Glasgow Precision Oncology Laboratory,; Australian Pancreatic Cancer Genome Initiative; Johns A, Pajic M, Froeling FEM, Beer P, Musgrove EA, Petersen GM, Ashworth A, Frame MC, Crawford HC, Simeone DM, Lord C, Mukhopadhyay D, Pilarsky C, Tuveson DA, Cooke SL, Jamieson NB, Morton JP, Sansom OJ, Bailey PJ, Biankin AV, Chang DK. Dreyer SB, et al. Among authors: chang dk. Gastroenterology. 2021 Jan;160(1):362-377.e13. doi: 10.1053/j.gastro.2020.09.043. Epub 2020 Oct 9. Gastroenterology. 2021. PMID: 33039466 Free PMC article.
CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer.
Pennel KA, Quinn JA, Nixon C, Inthagard J, van Wyk HC, Chang D, Rebus S; GPOL Group; Hay J, Maka NN, Roxburgh CS, Horgan PG, McMillan DC, Park JH, Roseweir AK, Steele CW, Edwards J. Pennel KA, et al. J Pathol Clin Res. 2022 Nov;8(6):509-520. doi: 10.1002/cjp2.290. Epub 2022 Jul 25. J Pathol Clin Res. 2022. PMID: 35879507 Free PMC article.
491 results