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420 results

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Page 1
Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging.
Yu YC, Tong ZJ, Liang XT, Wu JZ, Xu YJ, Wang JJ, Zhang MY, Wei TH, Yang J, Wang YB, Wang QX, Li QQ, Wang Z, Leng X, Ding N, Xue X, Sun SL, Li NG, Wang XL. Yu YC, et al. Among authors: wang jj, wang z, wang xl, wang qx, wang yb. J Med Chem. 2024 Mar 14;67(5):4194-4224. doi: 10.1021/acs.jmedchem.4c00058. Epub 2024 Mar 5. J Med Chem. 2024. PMID: 38442261
Discovery of 4-(4-aminophenyl)-6-phenylisoxazolo[3,4-b]pyridine-3-amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia.
Wang QX, Wang YB, Sha JK, Zhou H, Liu JC, Wu JZ, Tong ZJ, Cai J, Chen ZJ, Zhang CQ, Zheng XR, Wang JJ, Wang XL, Xue X, Yu YC, Ding N, Leng XJ, Dai WC, Sun SL, Chang L, Li NG, Shi ZH. Wang QX, et al. Among authors: wang jj, wang xl, wang yb. Drug Dev Res. 2023 Apr;84(2):296-311. doi: 10.1002/ddr.22032. Epub 2023 Jan 16. Drug Dev Res. 2023. PMID: 36644989
Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II.
Wang QX, Cao YH, Yang LJ, Ma YY, Li N, Wu SH, Chen L, Wu JZ, Tong ZJ, Wang XL, Xue X, Ding N, Leng XJ, Chang L, Dai WC, Yu YC, Sun SL, Yang Y, Li NG, Shi ZH. Wang QX, et al. Among authors: wang xl. Future Med Chem. 2023 Jan;15(1):57-71. doi: 10.4155/fmc-2022-0231. Epub 2023 Jan 18. Future Med Chem. 2023. PMID: 36651264
Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia.
Sun SL, Wu JZ, Wang JJ, Zhou H, Zhang CQ, Tong ZJ, Wang YB, Sha JK, Wang QX, Liu JC, Zheng XR, Li QQ, Zhang MY, Yang J, Wei TH, Wang ZX, Yu YC, Ding N, Leng XJ, Xue X, Li HM, Dai WC, Yin XY, Yang Y, Duan JA, Li NG, Shi ZH. Sun SL, et al. Among authors: wang zx, wang jj, wang qx, wang yb. Biomed Pharmacother. 2023 Dec 31;169:115905. doi: 10.1016/j.biopha.2023.115905. Epub 2023 Nov 24. Biomed Pharmacother. 2023. PMID: 38000356 Free article.
Correction to "Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging".
Yu YC, Tong ZJ, Liang XT, Wu JZ, Xu YJ, Wang JJ, Zhang MY, Wei TH, Yang J, Wang YB, Wang QX, Li QQ, Wang ZX, Leng XJ, Ding N, Xue X, Sun SL, Li NG, Wang XL. Yu YC, et al. Among authors: wang zx, wang jj, wang xl, wang qx, wang yb. J Med Chem. 2024 Apr 11;67(7):5960-5961. doi: 10.1021/acs.jmedchem.4c00606. Epub 2024 Mar 26. J Med Chem. 2024. PMID: 38530955 No abstract available.
Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation.
Wang QX, Cai J, Chen ZJ, Liu JC, Wang JJ, Zhou H, Li QQ, Wang ZX, Wang YB, Tong ZJ, Yang J, Wei TH, Zhang MY, Zhou Y, Dai WC, Ding N, Leng XJ, Yin XY, Sun SL, Yu YC, Li NG, Shi ZH. Wang QX, et al. Among authors: wang zx, wang jj, wang yb. Mol Inform. 2024 Sep;43(9):e202300336. doi: 10.1002/minf.202300336. Epub 2024 Jun 21. Mol Inform. 2024. PMID: 39031899
Discovery of 1-(Phenylsulfonyl)-1,2,3,4-tetrahydroquinoline Derivative as Orally Bioavailable and Safe RORγt Inverse Agonists for Potential Treatment of Rheumatoid Arthritis.
Sun SL, Xu HJ, Jiang XL, Zhou J, Shi W, Wang XJ, Song W, Chang XY, Ma XQ, Zou XF, Wu SH, Yang J, Li QQ, Wang ZX, Cai J, Yu SP, Wang QX, Wei TH, Wu JZ, Tong ZJ, Zhou Y, Wang YB, Yu YC, Leng XJ, Ding N, Shi ZH, Dai WC, Xue X, Li NG, Wang XL. Sun SL, et al. Among authors: wang qx. J Med Chem. 2024 Nov 28;67(22):20315-20342. doi: 10.1021/acs.jmedchem.4c01727. Epub 2024 Nov 15. J Med Chem. 2024. PMID: 39546350
420 results