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Page 1
Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
DeRatt LG, Zhang Z, Pietsch C, Cisar JS, Zhang X, Wang W, Tanner A, Matico R, Shaffer P, Jacoby E, Kazmi F, Shukla N, Bush TL, Patrick A, Philippar U, Attar R, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: jacoby e. J Med Chem. 2024 Jul 11;67(13):11254-11272. doi: 10.1021/acs.jmedchem.4c00809. Epub 2024 Jun 18. J Med Chem. 2024. PMID: 38889244
Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.
Kesteleyn B, Herschke F, Darville N, Stoops B, Jacobs T, Jacoby E, Shaffer P, Lammens L, Van Rompaey D, Matcha K, Martinez Lamenca C, Coesemans E, Hache G, Pieters S, Lecomte M, Hu L, Demin S, Milligan C, Abeywickrema P, De Bruyn S, Van Den Berg J, Ysebaert N, De Zwart L, Nájera I, Rigaux P, Roymans D, Jonckers THM. Kesteleyn B, et al. Among authors: jacoby e. J Med Chem. 2024 Jul 11;67(13):10986-11002. doi: 10.1021/acs.jmedchem.4c00514. Epub 2024 Jun 26. J Med Chem. 2024. PMID: 38932487
Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors.
Grosse S, Cooymans L, Embrechts W, McGowan D, Jacoby E, Stoops B, Gupta K, Ackermann M, Alnajjar S, Guillemont J, Jin Z, Kesteleyn B, Matcha K, Sriboonyapirat P, Truong A, Van Den Berg J, Yu X, Herschke F, Roymans D, Raboisson P, Rigaux P, Jonckers THM. Grosse S, et al. Among authors: jacoby e. J Med Chem. 2024 Aug 22;67(16):13723-13736. doi: 10.1021/acs.jmedchem.4c00525. Epub 2024 Aug 6. J Med Chem. 2024. PMID: 39105710
Identification of isoquinolinone DHODH inhibitor isosteres.
DeRatt LG, Zhang Z, Pietsch EC, Cisar J, Wang A, Wang CY, Tanner A, Shaffer P, Jacoby E, Kazmi F, Shukla N, Philippar U, Attar RM, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: jacoby e. Bioorg Med Chem Lett. 2024 Nov 15;113:129965. doi: 10.1016/j.bmcl.2024.129965. Epub 2024 Sep 14. Bioorg Med Chem Lett. 2024. PMID: 39284456
Structure-Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors.
Tran MT, Grosse S, Carbajo RJ, Jacoby E, Yin Y, Yu X, Martinez C, Stoops B, Cooymans L, Hu L, Lutter FH, Pieters S, Tan E, Alcázar J, Roymans D, van Vlijmen H, Rigaux P, Sharma S, Jonckers THM. Tran MT, et al. Among authors: jacoby e. ACS Med Chem Lett. 2024 Aug 2;15(9):1549-1558. doi: 10.1021/acsmedchemlett.4c00272. eCollection 2024 Sep 12. ACS Med Chem Lett. 2024. PMID: 39291020
From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.
Grosse S, Tahri A, Raboisson P, Houpis Y, Stoops B, Jacoby E, Neefs JM, Van Loock M, Goethals O, Geluykens P, Bonfanti JF, Jonckers THM. Grosse S, et al. Among authors: jacoby e. ACS Med Chem Lett. 2022 Nov 28;13(12):1879-1884. doi: 10.1021/acsmedchemlett.2c00372. eCollection 2022 Dec 8. ACS Med Chem Lett. 2022. PMID: 36518706 Free PMC article.
Direct-acting antivirals for RSV treatment, a review.
Bonneux B, Jacoby E, Ceconi M, Stobbelaar K, Delputte P, Herschke F. Bonneux B, et al. Among authors: jacoby e. Antiviral Res. 2024 Sep;229:105948. doi: 10.1016/j.antiviral.2024.105948. Epub 2024 Jul 5. Antiviral Res. 2024. PMID: 38972604 Review.
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, Verheyen N, Shareef A, Sutto-Ortiz P, Ysebaert N, Van Vlijmen H, Jonckers THM, Herschke F, McLellan JS, Decroly E, Fearns R, Grosse S, Roymans D, Sharma S, Rigaux P, Jin Z. Yu X, et al. Among authors: jacoby e. Commun Biol. 2023 Oct 21;6(1):1074. doi: 10.1038/s42003-023-05451-4. Commun Biol. 2023. PMID: 37865687 Free PMC article.
222 results