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The genetic architecture of multimodal human brain age.
Wen J, Zhao B, Yang Z, Erus G, Skampardoni I, Mamourian E, Cui Y, Hwang G, Bao J, Boquet-Pujadas A, Zhou Z, Veturi Y, Ritchie MD, Shou H, Thompson PM, Shen L, Toga AW, Davatzikos C. Wen J, et al. Among authors: shen l. Nat Commun. 2024 Mar 23;15(1):2604. doi: 10.1038/s41467-024-46796-6. Nat Commun. 2024. PMID: 38521789 Free PMC article.
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.
Shen L, Kim S, Risacher SL, Nho K, Swaminathan S, West JD, Foroud T, Pankratz N, Moore JH, Sloan CD, Huentelman MJ, Craig DW, Dechairo BM, Potkin SG, Jack CR Jr, Weiner MW, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative. Shen L, et al. Neuroimage. 2010 Nov 15;53(3):1051-63. doi: 10.1016/j.neuroimage.2010.01.042. Epub 2010 Jan 25. Neuroimage. 2010. PMID: 20100581 Free PMC article.
Voxelwise genome-wide association study (vGWAS).
Stein JL, Hua X, Lee S, Ho AJ, Leow AD, Toga AW, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Dechairo BM, Potkin SG, Weiner MW, Thompson P; Alzheimer's Disease Neuroimaging Initiative. Stein JL, et al. Among authors: shen l. Neuroimage. 2010 Nov 15;53(3):1160-74. doi: 10.1016/j.neuroimage.2010.02.032. Epub 2010 Feb 17. Neuroimage. 2010. PMID: 20171287 Free PMC article.
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
Stein JL, Hua X, Morra JH, Lee S, Hibar DP, Ho AJ, Leow AD, Toga AW, Sul JH, Kang HM, Eskin E, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, Webster J, DeChairo BM, Potkin SG, Jack CR Jr, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Stein JL, et al. Among authors: shen l. Neuroimage. 2010 Jun;51(2):542-54. doi: 10.1016/j.neuroimage.2010.02.068. Epub 2010 Mar 1. Neuroimage. 2010. PMID: 20197096 Free PMC article.
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.
Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, Dinov ID, Toga AW, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, DeCarli CS, DeChairo BM, Potkin SG, Jack CR Jr, Weiner MW, Raji CA, Lopez OL, Becker JT, Carmichael OT, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Ho AJ, et al. Among authors: shen l. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8404-9. doi: 10.1073/pnas.0910878107. Epub 2010 Apr 19. Proc Natl Acad Sci U S A. 2010. PMID: 20404173 Free PMC article.
Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects.
Hibar DP, Stein JL, Kohannim O, Jahanshad N, Saykin AJ, Shen L, Kim S, Pankratz N, Foroud T, Huentelman MJ, Potkin SG, Jack CR Jr, Weiner MW, Toga AW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Hibar DP, et al. Among authors: shen l. Neuroimage. 2011 Jun 15;56(4):1875-91. doi: 10.1016/j.neuroimage.2011.03.077. Epub 2011 Apr 8. Neuroimage. 2011. PMID: 21497199 Free PMC article.
Identification of common variants associated with human hippocampal and intracranial volumes.
Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Mattingsdal M, Mohnke S, Maniega SM, Nho K, Nugent AC, O'Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M, Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N, Johnson MP, Kasperaviciute D, Kent JW Jr, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME,… See abstract for full author list ➔ Stein JL, et al. Among authors: shen l. Nat Genet. 2012 Apr 15;44(5):552-61. doi: 10.1038/ng.2250. Nat Genet. 2012. PMID: 22504417 Free PMC article.
Predicting brain activity using a Bayesian spatial model.
Derado G, Bowman FD, Zhang L; Alzheimer's Disease Neuroimaging Initiative Investigators. Derado G, et al. Stat Methods Med Res. 2013 Aug;22(4):382-97. doi: 10.1177/0962280212448972. Epub 2012 Jun 28. Stat Methods Med Res. 2013. PMID: 22743280 Free PMC article.
Rates of decline in Alzheimer disease decrease with age.
Holland D, Desikan RS, Dale AM, McEvoy LK; Alzheimer’s Disease Neuroimaging Initiative. Holland D, et al. PLoS One. 2012;7(8):e42325. doi: 10.1371/journal.pone.0042325. Epub 2012 Aug 2. PLoS One. 2012. PMID: 22876315 Free PMC article.
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