Flaherty DP - Search Results

1

Biochemical pharmacology of adenylyl cyclases in cancer.

Chandra Jena B, Flaherty DP, O'Brien VP, Watts VJ. Chandra Jena B, et al. Among authors: flaherty dp. Biochem Pharmacol. 2024 Oct;228:116160. doi: 10.1016/j.bcp.2024.116160. Epub 2024 Mar 24. Biochem Pharmacol. 2024. PMID: 38522554 Review.

2

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca²⁺/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP. Kaur J, et al. Among authors: flaherty dp. Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30472604 Free PMC article.

3

High-content phenotypic screening identifies novel chemistries that disrupt mosquito activity and development.

Murgia MV, Sharan S, Kaur J, Austin W, Hagen L, Wu L, Chen L, Scott JA, Flaherty DP, Scharf ME, Watts VJ, Hill CA. Murgia MV, et al. Among authors: flaherty dp. Pestic Biochem Physiol. 2022 Mar;182:105037. doi: 10.1016/j.pestbp.2022.105037. Epub 2022 Jan 10. Pestic Biochem Physiol. 2022. PMID: 35249647 Free article.

4

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca²⁺/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.

Scott JA, Soto-Velasquez M, Hayes MP, LaVigne JE, Miller HR, Kaur J, Ejendal KFK, Watts VJ, Flaherty DP. Scott JA, et al. Among authors: flaherty dp. J Med Chem. 2022 Mar 24;65(6):4667-4686. doi: 10.1021/acs.jmedchem.1c01759. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271288 Free PMC article.

5

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype.

Dwyer TS, O'Brien JB, Ptak CP, LaVigne JE, Flaherty DP, Watts VJ, Roman DL. Dwyer TS, et al. Among authors: flaherty dp. Front Pharmacol. 2022 Sep 6;13:977742. doi: 10.3389/fphar.2022.977742. eCollection 2022. Front Pharmacol. 2022. PMID: 36147328 Free PMC article.

6

Pyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain.

Shrinidhi A, Dwyer TS, Scott JA, Watts VJ, Flaherty DP. Shrinidhi A, et al. Among authors: flaherty dp. J Med Chem. 2024 Oct 24;67(20):18290-18316. doi: 10.1021/acs.jmedchem.4c01645. Epub 2024 Oct 15. J Med Chem. 2024. PMID: 39404162

7

Evaluation of 1,3,4-Thiadiazole Carbonic Anhydrase Inhibitors for Gut Decolonization of Vancomycin-Resistant Enterococci.

Abutaleb NS, Shrinidhi A, Bandara AB, Seleem MN, Flaherty DP. Abutaleb NS, et al. Among authors: flaherty dp. ACS Med Chem Lett. 2023 Mar 21;14(4):487-492. doi: 10.1021/acsmedchemlett.3c00032. eCollection 2023 Apr 13. ACS Med Chem Lett. 2023. PMID: 37077393 Free PMC article.

8

Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation.

Camara A, Chugh H, George A, Dolidze L, Ryu K, Holly KJ, Flaherty DP, Mattoo S. Camara A, et al. Among authors: flaherty dp. Cell Stress Chaperones. 2024 Jun;29(3):404-424. doi: 10.1016/j.cstres.2024.04.001. Epub 2024 Apr 9. Cell Stress Chaperones. 2024. PMID: 38599565 Free PMC article.

9

Neisseria gonorrhoeae carbonic anhydrase inhibition.

Youse MS, Holly KJ, Flaherty DP. Youse MS, et al. Among authors: flaherty dp. Enzymes. 2024;55:243-281. doi: 10.1016/bs.enz.2024.05.008. Epub 2024 Jun 6. Enzymes. 2024. PMID: 39222993 Review.

10

Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA.

Colquhoun JM, Ha L, Beckley A, Meyers B, Flaherty DP, Dunman PM. Colquhoun JM, et al. Among authors: flaherty dp. Antibiotics (Basel). 2019 Apr 28;8(2):48. doi: 10.3390/antibiotics8020048. Antibiotics (Basel). 2019. PMID: 31035380 Free PMC article.

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