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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.
Graham K, Lienau P, Bader B, Prechtl S, Naujoks J, Lesche R, Weiske J, Kuehnlenz J, Brzezinka K, Potze L, Zanconato F, Nicke B, Montebaur A, Bone W, Golfier S, Kaulfuss S, Kopitz C, Pilari S, Steuber H, Hayat S, Kamburov A, Steffen A, Schlicker A, Buchgraber P, Braeuer N, Font NA, Heinrich T, Kuhnke L, Nowak-Reppel K, Stresemann C, Steigemann P, Walter AO, Blotta S, Ocker M, Lakner A, von Nussbaum F, Mumberg D, Eis K, Piccolo S, Lange M. Graham K, et al. Among authors: steigemann p. Cell Chem Biol. 2024 Jul 18;31(7):1247-1263.e16. doi: 10.1016/j.chembiol.2024.02.013. Epub 2024 Mar 26. Cell Chem Biol. 2024. PMID: 38537632
Chromosome Missegregation Associated with RUVBL1 Deficiency.
Gentili C, Castor D, Kaden S, Lauterbach D, Gysi M, Steigemann P, Gerlich DW, Jiricny J, Ferrari S. Gentili C, et al. Among authors: steigemann p. PLoS One. 2015 Jul 22;10(7):e0133576. doi: 10.1371/journal.pone.0133576. eCollection 2015. PLoS One. 2015. PMID: 26201077 Free PMC article.
3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions.
Wenzel C, Riefke B, Gründemann S, Krebs A, Christian S, Prinz F, Osterland M, Golfier S, Räse S, Ansari N, Esner M, Bickle M, Pampaloni F, Mattheyer C, Stelzer EH, Parczyk K, Prechtl S, Steigemann P. Wenzel C, et al. Among authors: steigemann p. Exp Cell Res. 2014 Apr 15;323(1):131-143. doi: 10.1016/j.yexcr.2014.01.017. Epub 2014 Jan 27. Exp Cell Res. 2014. PMID: 24480576 Free article.
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
Mortier J, Friberg A, Badock V, Moosmayer D, Schroeder J, Steigemann P, Siegel F, Gradl S, Bauser M, Hillig RC, Briem H, Eis K, Bader B, Nguyen D, Christ CD. Mortier J, et al. Among authors: steigemann p. ChemMedChem. 2020 May 19;15(10):827-832. doi: 10.1002/cmdc.201900727. Epub 2020 Apr 1. ChemMedChem. 2020. PMID: 32237114 Free PMC article.
21 results