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Page 1
Integration of multi-omics layers empowers precision diagnosis through unveiling pathogenic mechanisms on maple syrup urine disease.
Tejedor JR, Soriano-Sexto A, Beccari L, Castejón-Fernández N, Correcher P, Sainz-Ledo L, Alba-Linares JJ, Urdinguio RG, Ugarte M, Fernández AF, Rodríguez-Pombo P, Fraga MF, Pérez B. Tejedor JR, et al. Among authors: alba linares jj. J Inherit Metab Dis. 2025 Jan;48(1):e12829. doi: 10.1002/jimd.12829. Epub 2024 Dec 10. J Inherit Metab Dis. 2025. PMID: 39659154 Free PMC article.
A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment.
Pérez RF, Tezanos P, Peñarroya A, González-Ramón A, Urdinguio RG, Gancedo-Verdejo J, Tejedor JR, Santamarina-Ojeda P, Alba-Linares JJ, Sainz-Ledo L, Roberti A, López V, Mangas C, Moro M, Cintado Reyes E, Muela Martínez P, Rodríguez-Santamaría M, Ortea I, Iglesias-Rey R, Castilla-Silgado J, Tomás-Zapico C, Iglesias-Gutiérrez E, Fernández-García B, Sanchez-Mut JV, Trejo JL, Fernández AF, Fraga MF. Pérez RF, et al. Among authors: alba linares jj. Nat Commun. 2024 Jul 16;15(1):5829. doi: 10.1038/s41467-024-49608-z. Nat Commun. 2024. PMID: 39013876 Free PMC article.
A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma.
Rey V, Tornín J, Alba-Linares JJ, Robledo C, Murillo D, Rodríguez A, Gallego B, Huergo C, Viera C, Braña A, Astudillo A, Heymann D, Szuhai K, Bovée JVMG, Fernández AF, Fraga MF, Alonso J, Rodríguez R. Rey V, et al. Among authors: alba linares jj. EBioMedicine. 2024 Apr;102:105090. doi: 10.1016/j.ebiom.2024.105090. Epub 2024 Mar 27. EBioMedicine. 2024. PMID: 38547578 Free PMC article.
CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer.
Tejedor JR, Peñarroya A, Gancedo-Verdejo J, Santamarina-Ojeda P, Pérez RF, López-Tamargo S, Díez-Borge A, Alba-Linares JJ, González-Del-Rey N, Urdinguio RG, Mangas C, Roberti A, López V, Morales-Ruiz T, Ariza RR, Roldán-Arjona T, Meijón M, Valledor L, Cañal MJ, Fernández-Martínez D, Fernández-Hevia M, Jiménez-Fonseca P, García-Flórez LJ, Fernández AF, Fraga MF. Tejedor JR, et al. Among authors: alba linares jj. Clin Epigenetics. 2023 Aug 24;15(1):133. doi: 10.1186/s13148-023-01546-1. Clin Epigenetics. 2023. PMID: 37612734 Free PMC article.
Enhanced Detection of Viral RNA Species Using FokI-Assisted Digestion of DNA Duplexes and DNA/RNA Hybrids.
Tejedor JR, Martín G, Roberti A, Mangas C, Santamarina-Ojeda P, Fernández Pérez R, López V, González Urdinguio R, Alba-Linares JJ, Peñarroya A, Álvarez-Argüelles ME, Boga JA, Fernández Fernández A, Rojo-Alba S, Fernández Fraga M. Tejedor JR, et al. Among authors: alba linares jj. Anal Chem. 2022 May 10;94(18):6760-6770. doi: 10.1021/acs.analchem.2c00407. Epub 2022 Apr 25. Anal Chem. 2022. PMID: 35467835 Free PMC article.
Blood DNA Methylation Patterns in Older Adults With Evolving Dementia.
Pérez RF, Alba-Linares JJ, Tejedor JR, Fernández AF, Calero M, Román-Domínguez A, Borrás C, Viña J, Ávila J, Medina M, Fraga MF. Pérez RF, et al. Among authors: alba linares jj. J Gerontol A Biol Sci Med Sci. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. J Gerontol A Biol Sci Med Sci. 2022. PMID: 35299244 Free PMC article.