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Off-target effects by siRNA can induce toxic phenotype.
Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A. Fedorov Y, et al. Among authors: khvorova a. RNA. 2006 Jul;12(7):1188-96. doi: 10.1261/rna.28106. Epub 2006 May 8. RNA. 2006. PMID: 16682561 Free PMC article.
Rational siRNA design for RNA interference.
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Reynolds A, et al. Among authors: khvorova a. Nat Biotechnol. 2004 Mar;22(3):326-30. doi: 10.1038/nbt936. Epub 2004 Feb 1. Nat Biotechnol. 2004. PMID: 14758366 Free article.
RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.
Wilson JA, Jayasena S, Khvorova A, Sabatinos S, Rodrigue-Gervais IG, Arya S, Sarangi F, Harris-Brandts M, Beaulieu S, Richardson CD. Wilson JA, et al. Among authors: khvorova a. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2783-8. doi: 10.1073/pnas.252758799. Epub 2003 Feb 19. Proc Natl Acad Sci U S A. 2003. PMID: 12594341 Free PMC article.
154 results