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Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model.
Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Chung HJ, Blair NS, Millay DP, Morris AJ, Prideaux B, Finck BN, Quattrocelli M. Prabakaran AD, et al. Among authors: durumutla hb. J Clin Invest. 2024 May 3;134(11):e177427. doi: 10.1172/JCI177427. J Clin Invest. 2024. PMID: 38702076 Free PMC article.
Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival.
Goswami MT, Weh E, Subramanya S, Weh KM, Durumutla HB, Hager H, Miller N, Chaudhury S, Andren A, Sajjakulnukit P, Zhang L, Besirli CG, Lyssiotis CA, Wubben TJ. Goswami MT, et al. Among authors: durumutla hb. bioRxiv [Preprint]. 2024 Jul 1:2024.03.26.582525. doi: 10.1101/2024.03.26.582525. bioRxiv. 2024. PMID: 38586045 Free PMC article. Preprint.
The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle.
Prabakaran AD, Chung HJ, McFarland K, Govindarajan T, El Abdellaoui Soussi F, Durumutla HB, Villa C, Piczer K, Latimer H, Werbrich C, Akinborewa O, Horning R, Quattrocelli M. Prabakaran AD, et al. Among authors: durumutla hb. bioRxiv [Preprint]. 2024 Mar 31:2024.03.28.586997. doi: 10.1101/2024.03.28.586997. bioRxiv. 2024. PMID: 38585940 Free PMC article. Preprint.
Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation.
Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Blair NS, Millay DP, Prideaux B, Finck BN, Quattrocelli M. Prabakaran AD, et al. Among authors: durumutla hb. bioRxiv [Preprint]. 2023 Oct 19:2023.10.16.562573. doi: 10.1101/2023.10.16.562573. bioRxiv. 2023. PMID: 37905062 Free PMC article. Preprint.