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Page 1
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury.
Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis II, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG. Morral C, et al. Among authors: koumenis c. Nat Commun. 2024 Apr 8;15(1):3018. doi: 10.1038/s41467-024-47124-8. Nat Commun. 2024. PMID: 38589357 Free PMC article.
FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease.
Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SAO, Kokkorakis M, Koliaki I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II. Kim K, et al. Among authors: koumenis c. Int J Radiat Oncol Biol Phys. 2024 Jul 15;119(4):1234-1247. doi: 10.1016/j.ijrobp.2024.01.224. Epub 2024 Feb 15. Int J Radiat Oncol Biol Phys. 2024. PMID: 38364948 Free PMC article.
Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: the paradigm of radiotherapy.
Logotheti S, Pavlopoulou A, Rudsari HK, Galow AM, Kafalı Y, Kyrodimos E, Giotakis AI, Marquardt S, Velalopoulou A, Verginadis II, Koumenis C, Stiewe T, Zoidakis J, Balasingham I, David R, Georgakilas AG. Logotheti S, et al. Among authors: koumenis c. Pharmacol Ther. 2024 Aug;260:108670. doi: 10.1016/j.pharmthera.2024.108670. Epub 2024 May 31. Pharmacol Ther. 2024. PMID: 38823489 Review.
Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.
Amit U, Uslu U, Verginadis II, Kim MM, Motlagh SAO, Diffenderfer ES, Assenmacher CA, Bicher S, Atoche SJ, Ben-Josef E, Young RM, June CH, Koumenis C. Amit U, et al. Among authors: koumenis c. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2403002121. doi: 10.1073/pnas.2403002121. Epub 2024 Jul 24. Proc Natl Acad Sci U S A. 2024. PMID: 39047033 Free PMC article.
Early Inflammation and Interferon Signaling Direct Enhanced Intestinal Crypt Regeneration after Proton FLASH Radiotherapy.
Lim TL, Morral C, Verginadis II, Kim K, Luo L, Foley CJ, Kim MM, Li N, Yoshor B, Njah K, Putt M, Oliaei Motlagh SA, Velalopoulou A, Chowdhury P, Bicher S, Goia D, Lengner CJ, Wrana JL, Koumenis C, Minn AJ. Lim TL, et al. Among authors: koumenis c. bioRxiv [Preprint]. 2024 Aug 19:2024.08.16.608284. doi: 10.1101/2024.08.16.608284. bioRxiv. 2024. PMID: 39229237 Free PMC article. Preprint.
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.
Verginadis II, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Oliaei Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM. Verginadis II, et al. Among authors: koumenis c. bioRxiv [Preprint]. 2024 Jul 11:2024.07.08.602528. doi: 10.1101/2024.07.08.602528. bioRxiv. 2024. PMID: 39026805 Free PMC article. Preprint.
Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltration.
Kostopoulos N, Costabile F, Krimitza E, Beghi S, Goia D, Perales-Linares R, Thyfronitis G, LaRiviere MJ, Chong EA, Schuster SJ, Maity A, Koumenis C, Plastaras JP, Facciabene A. Kostopoulos N, et al. Among authors: koumenis c. Blood Adv. 2024 Dec 24;8(24):6308-6320. doi: 10.1182/bloodadvances.2024012599. Blood Adv. 2024. PMID: 39213422 Free PMC article.
Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.
Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield A, Bykova K, Guo W, Fan Y, Buynov NM, Diehl JA, Stanger BZ, Tachibana H, Gade TP, Puré E, Koumenis C, Bolotin EM, Fuchs SY. Lu Z, et al. Among authors: koumenis c. Sci Transl Med. 2024 Aug 21;16(761):eadn0904. doi: 10.1126/scitranslmed.adn0904. Epub 2024 Aug 21. Sci Transl Med. 2024. PMID: 39167664
168 results