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Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation.
Rombaut D, Lefèvre C, Rached T, Bondu S, Letessier A, Mangione RM, Farhat B, Lesieur-Pasquier A, Castillo-Guzman D, Boussaid I, Friedrich C, Tourville A, De Carvalho M, Levavasseur F, Leduc M, Le Gall M, Battault S, Temple M, Houy A, Bouscary D, Willems L, Park S, Raynaud S, Cluzeau T, Clappier E, Fenaux P, Adès L, Margueron R, Wassef M, Alsafadi S, Chapuis N, Kosmider O, Solary E, Constantinou A, Stern MH, Droin N, Palancade B, Miotto B, Chédin F, Fontenay M. Rombaut D, et al. Among authors: margueron r. Nat Commun. 2024 Apr 8;15(1):3016. doi: 10.1038/s41467-024-46547-7. Nat Commun. 2024. PMID: 38589367 Free PMC article.
The Multiple Facets of PRC2 Alterations in Cancers.
Wassef M, Margueron R. Wassef M, et al. Among authors: margueron r. J Mol Biol. 2017 Jun 30;429(13):1978-1993. doi: 10.1016/j.jmb.2016.10.012. Epub 2016 Oct 12. J Mol Biol. 2017. PMID: 27742591 Review.
BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.
Campagne A, Lee MK, Zielinski D, Michaud A, Le Corre S, Dingli F, Chen H, Shahidian LZ, Vassilev I, Servant N, Loew D, Pasmant E, Postel-Vinay S, Wassef M, Margueron R. Campagne A, et al. Among authors: margueron r. Nat Commun. 2019 Jan 21;10(1):348. doi: 10.1038/s41467-018-08255-x. Nat Commun. 2019. PMID: 30664650 Free PMC article.
EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.
Wassef M, Luscan A, Aflaki S, Zielinski D, Jansen PWTC, Baymaz HI, Battistella A, Kersouani C, Servant N, Wallace MR, Romero P, Kosmider O, Just PA, Hivelin M, Jacques S, Vincent-Salomon A, Vermeulen M, Vidaud M, Pasmant E, Margueron R. Wassef M, et al. Among authors: margueron r. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6075-6080. doi: 10.1073/pnas.1814634116. Epub 2019 Mar 13. Proc Natl Acad Sci U S A. 2019. PMID: 30867289 Free PMC article.
A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.
Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M. Bondu S, et al. Among authors: margueron r. Sci Transl Med. 2019 Jul 10;11(500):eaav5467. doi: 10.1126/scitranslmed.aav5467. Sci Transl Med. 2019. PMID: 31292266 Free PMC article. Clinical Trial.
"MPNST Epigenetics"-Letter.
Wassef M, Pasmant E, Margueron R. Wassef M, et al. Among authors: margueron r. Mol Cancer Res. 2019 Oct;17(10):2139. doi: 10.1158/1541-7786.MCR-19-0680. Mol Cancer Res. 2019. PMID: 31575727 Free article. No abstract available.
76 results