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Page 1
The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.
Henis M, Rücker T, Scharrenberg R, Richter M, Baltussen L, Hong S, Meka DP, Schwanke B, Neelagandan N, Daaboul D, Murtaza N, Krisp C, Harder S, Schlüter H, Kneussel M, Hermans-Borgmeyer I, de Wit J, Singh KK, Duncan KE, de Anda FC. Henis M, et al. Among authors: scharrenberg r. Sci Adv. 2024 Apr 12;10(15):eadf7001. doi: 10.1126/sciadv.adf7001. Epub 2024 Apr 12. Sci Adv. 2024. PMID: 38608030 Free PMC article.
TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model.
Scharrenberg R, Richter M, Johanns O, Meka DP, Rücker T, Murtaza N, Lindenmaier Z, Ellegood J, Naumann A, Zhao B, Schwanke B, Sedlacik J, Fiehler J, Hanganu-Opatz IL, Lerch JP, Singh KK, de Anda FC. Scharrenberg R, et al. Mol Psychiatry. 2022 Nov;27(11):4707-4721. doi: 10.1038/s41380-022-01785-3. Epub 2022 Sep 19. Mol Psychiatry. 2022. PMID: 36123424 Free PMC article.
Emerging roles of the centrosome in neuronal development.
Meka DP, Scharrenberg R, Calderon de Anda F. Meka DP, et al. Among authors: scharrenberg r. Cytoskeleton (Hoboken). 2020 Mar;77(3-4):84-96. doi: 10.1002/cm.21593. Epub 2020 Jan 20. Cytoskeleton (Hoboken). 2020. PMID: 31925901 Review.
Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.
Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G. Stanelle-Bertram S, et al. Among authors: scharrenberg r. Nat Microbiol. 2018 Oct;3(10):1161-1174. doi: 10.1038/s41564-018-0236-1. Epub 2018 Sep 10. Nat Microbiol. 2018. PMID: 30202017
Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.
Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RKC, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-Opatz IL, Morellini F, Scherer SW, Singh KK, Calderon de Anda F. Richter M, et al. Among authors: scharrenberg r. Mol Psychiatry. 2019 Sep;24(9):1329-1350. doi: 10.1038/s41380-018-0025-5. Epub 2018 Feb 21. Mol Psychiatry. 2019. PMID: 29467497 Free PMC article.
Microtubules Modulate F-actin Dynamics during Neuronal Polarization.
Zhao B, Meka DP, Scharrenberg R, König T, Schwanke B, Kobler O, Windhorst S, Kreutz MR, Mikhaylova M, Calderon de Anda F. Zhao B, et al. Among authors: scharrenberg r. Sci Rep. 2017 Aug 29;7(1):9583. doi: 10.1038/s41598-017-09832-8. Sci Rep. 2017. PMID: 28851982 Free PMC article.