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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.
Bretou M, Sannerud R, Escamilla-Ayala A, Leroy T, Vrancx C, Van Acker ZP, Perdok A, Vermeire W, Vorsters I, Van Keymolen S, Maxson M, Pavie B, Wierda K, Eskelinen EL, Annaert W. Bretou M, et al. Among authors: sannerud r. Dev Cell. 2024 Jun 17;59(12):1571-1592.e9. doi: 10.1016/j.devcel.2024.03.030. Epub 2024 Apr 15. Dev Cell. 2024. PMID: 38626765 Free article.
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.
Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Derua R, Waelkens E, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Van Niel G, De Strooper B, Annaert W. Sannerud R, et al. Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9. Cell. 2016. PMID: 27293189 Free PMC article.
Bin1 and CD2AP polarize Aβ generation in neurons.
Sannerud R, Annaert W. Sannerud R, et al. EMBO Rep. 2017 Jan;18(1):5-7. doi: 10.15252/embr.201643634. Epub 2016 Dec 19. EMBO Rep. 2017. PMID: 27993940 Free PMC article.
28 results