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Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment.
Raguz J, Pinto C, Pölzlbauer T, Habbeddine M, Rosskopf S, Strauß J, Just V, Schmidt S, Bidet Huang K, Stemeseder F, Schippers T, Stewart E, Jez J, Berraondo P, Orlinger KK, Lauterbach H. Raguz J, et al. Among authors: schmidt s. J Immunother Cancer. 2024 Apr 17;12(4):e008286. doi: 10.1136/jitc-2023-008286. J Immunother Cancer. 2024. PMID: 38631709 Free PMC article.
Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer.
Schmidt S, Bonilla WV, Reiter A, Stemeseder F, Kleissner T, Oeler D, Berka U, El-Gazzar A, Kiefmann B, Schulha SC, Raguz J, Habbeddine M, Scheinost M, Qing X, Lauterbach H, Matushansky I, Pinschewer DD, Orlinger KK. Schmidt S, et al. Oncoimmunology. 2020 Sep 15;9(1):1809960. doi: 10.1080/2162402X.2020.1809960. Oncoimmunology. 2020. PMID: 33457095 Free PMC article.
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Bonilla WV, Kirchhammer N, Marx AF, Kallert SM, Krzyzaniak MA, Lu M, Darbre S, Schmidt S, Raguz J, Berka U, Vincenti I, Pauzuolis M, Kerber R, Hoepner S, Günther S, Magnus C, Merkler D, Orlinger KK, Zippelius A, Pinschewer DD. Bonilla WV, et al. Among authors: schmidt s. Cell Rep Med. 2021 Mar 3;2(3):100209. doi: 10.1016/j.xcrm.2021.100209. eCollection 2021 Mar 16. Cell Rep Med. 2021. PMID: 33763654 Free PMC article.
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment.
Ring SS, Cupovic J, Onder L, Lütge M, Perez-Shibayama C, Gil-Cruz C, Scandella E, De Martin A, Mörbe U, Hartmann F, Wenger R, Spiegl M, Besse A, Bonilla WV, Stemeseder F, Schmidt S, Orlinger KK, Krebs P, Ludewig B, Flatz L. Ring SS, et al. Among authors: schmidt s. Nat Commun. 2021 Aug 5;12(1):4734. doi: 10.1038/s41467-021-25057-w. Nat Commun. 2021. PMID: 34354077 Free PMC article.
Development and Characterization of a Novel Non-Lytic Cancer Immunotherapy Using a Recombinant Arenavirus Vector Platform.
Lauterbach H, Schmidt S, Katchar K, Qing X, Iacobucci C, Hwang A, Schlienger K, Berka U, Raguz J, Ahmadi-Erber S, Schippers T, Stemeseder F, Pinschewer DD, Matushansky I, Orlinger KK. Lauterbach H, et al. Among authors: schmidt s. Front Oncol. 2021 Oct 14;11:732166. doi: 10.3389/fonc.2021.732166. eCollection 2021. Front Oncol. 2021. PMID: 34722273 Free PMC article. Review.
Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.
Schmidt S, Mengistu M, Daffis S, Ahmadi-Erber S, Deutschmann D, Grigoriev T, Chu R, Leung C, Tomkinson A, Uddin MN, Moshkani S, Robek MD, Perry J, Lauterbach H, Orlinger K, Fletcher SP, Balsitis S. Schmidt S, et al. J Infect Dis. 2024 Apr 12;229(4):1077-1087. doi: 10.1093/infdis/jiad340. J Infect Dis. 2024. PMID: 37602681
Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys.
Boopathy AV, Sharma B, Nekkalapudi A, Wimmer R, Gamez-Guerrero M, Suthram S, Truong H, Lee J, Li J, Martin R, Blair W, Geleziunas R, Orlinger K, Ahmadi-Erber S, Lauterbach H, Makadzange T, Falkard B, Schmidt S. Boopathy AV, et al. Among authors: schmidt s. NPJ Vaccines. 2023 Nov 10;8(1):175. doi: 10.1038/s41541-023-00768-x. NPJ Vaccines. 2023. PMID: 37945621 Free PMC article.
A replicating LCMV-based vaccine for the treatment of solid tumors.
Purde MT, Cupovic J, Palmowski YA, Makky A, Schmidt S, Rochwarger A, Hartmann F, Stemeseder F, Lercher A, Abdou MT, Bomze D, Besse L, Berner F, Tüting T, Hölzel M, Bergthaler A, Kochanek S, Ludewig B, Lauterbach H, Orlinger KK, Bald T, Schietinger A, Schürch C, Ring SS, Flatz L. Purde MT, et al. Among authors: schmidt s. Mol Ther. 2024 Feb 7;32(2):426-439. doi: 10.1016/j.ymthe.2023.11.026. Epub 2023 Dec 5. Mol Ther. 2024. PMID: 38058126 Free article.
Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques.
Boopathy AV, Nekkalapudi A, Sung J, Schulha S, Jin D, Sharma B, Ng S, Lu S, Wimmer R, Suthram S, Ahmadi-Erber S, Lauterbach H, Orlinger KK, Hung M, Carr B, Callebaut C, Geleziunas R, Kuhne M, Schmidt S, Falkard B. Boopathy AV, et al. Among authors: schmidt s. J Virol. 2024 Jul 23;98(7):e0029424. doi: 10.1128/jvi.00294-24. Epub 2024 Jun 3. J Virol. 2024. PMID: 38829139 Free PMC article.
Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates.
Sharma B, Bekerman E, Truong H, Lee J, Gamez-Guerrero M, Boopathy A, Mital R, Huang KB, Ahmadi-Erber S, Wimmer R, Schulha S, Lauterbach H, Orlinger K, Suthram S, Lewis MG, Blair W, Makadzange T, Geleziunas R, Murry JP, Schmidt S. Sharma B, et al. Among authors: schmidt s. Vaccines (Basel). 2024 Jul 2;12(7):735. doi: 10.3390/vaccines12070735. Vaccines (Basel). 2024. PMID: 39066373 Free PMC article.
5,524 results