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Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.
Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Rolas L, Dorado B, Nourshargh S, Hamczyk MR, Andrés V. Benedicto I, et al. Among authors: de la fuente perez m. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2400752121. doi: 10.1073/pnas.2400752121. Epub 2024 Apr 22. Proc Natl Acad Sci U S A. 2024. PMID: 38648484 Free PMC article.
Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction.
Del Monte-Monge A, Ruiz-Polo de Lara Í, Gonzalo P, Espinós-Estévez C, González-Amor M, de la Fuente-Pérez M, Andrés-Manzano MJ, Fanjul V, Gimeno JR, Barriales-Villa R, Dorado B, Andrés V. Del Monte-Monge A, et al. Among authors: de la fuente perez m. Int J Mol Sci. 2023 Jul 6;24(13):11172. doi: 10.3390/ijms241311172. Int J Mol Sci. 2023. PMID: 37446344 Free PMC article.
Endothelial cell-specific progerin expression does not cause cardiovascular alterations and premature death.
Benedicto I, Hamczyk MR, Nevado RM, Barettino A, Carmona RM, Espinós-Estévez C, Gonzalo P, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Dorado B, Andrés V. Benedicto I, et al. Among authors: de la fuente perez m. Aging Cell. 2024 Oct 31:e14389. doi: 10.1111/acel.14389. Online ahead of print. Aging Cell. 2024. PMID: 39479939 Free article.