Brenk R - Search Results

1

Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.

Jalencas X, Berg H, Espeland LO, Sreeramulu S, Kinnen F, Richter C, Georgiou C, Yadrykhinsky V, Specker E, Jaudzems K, Miletić T, Harmel R, Gribbon P, Schwalbe H, Brenk R, Jirgensons A, Zaliani A, Mestres J. Jalencas X, et al. Among authors: brenk r. RSC Med Chem. 2024 Feb 12;15(4):1176-1188. doi: 10.1039/d3md00724c. eCollection 2024 Apr 24. RSC Med Chem. 2024. PMID: 38665834 Free PMC article.

2

Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics.

Yadrykhins'ky V, Georgiou C, Brenk R. Yadrykhins'ky V, et al. Among authors: brenk r. F1000Res. 2021 Nov 1;10:Chem Inf Sci-1102. doi: 10.12688/f1000research.74018.2. eCollection 2021. F1000Res. 2021. PMID: 35136566 Free PMC article.

3

An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics.

Espeland LO, Georgiou C, Klein R, Bhukya H, Haug BE, Underhaug J, Mainkar PS, Brenk R. Espeland LO, et al. Among authors: brenk r. ChemMedChem. 2021 Sep 6;16(17):2715-2726. doi: 10.1002/cmdc.202100302. Epub 2021 Aug 6. ChemMedChem. 2021. PMID: 34189850 Free PMC article.

4

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97.

Bothe S, Hänzelmann P, Böhler S, Kehrein J, Zehe M, Wiedemann C, Hellmich UA, Brenk R, Schindelin H, Sotriffer C. Bothe S, et al. Among authors: brenk r. Commun Chem. 2022 Dec 7;5(1):169. doi: 10.1038/s42004-022-00782-5. Commun Chem. 2022. PMID: 36697690 Free PMC article.

5

Ligand design for riboswitches, an emerging target class for novel antibiotics.

Rekand IH, Brenk R. Rekand IH, et al. Among authors: brenk r. Future Med Chem. 2017 Sep;9(14):1649-1663. doi: 10.4155/fmc-2017-0063. Epub 2017 Sep 19. Future Med Chem. 2017. PMID: 28925284 Review.

6

How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System.

Kersten C, Fleischer E, Kehrein J, Borek C, Jaenicke E, Sotriffer C, Brenk R. Kersten C, et al. Among authors: brenk r. J Med Chem. 2020 Mar 12;63(5):2095-2113. doi: 10.1021/acs.jmedchem.9b00586. Epub 2019 Aug 19. J Med Chem. 2020. PMID: 31423787

7

Fragment-Based Drug Discovery for RNA Targets.

Lundquist KP, Panchal V, Gotfredsen CH, Brenk R, Clausen MH. Lundquist KP, et al. Among authors: brenk r. ChemMedChem. 2021 Sep 6;16(17):2588-2603. doi: 10.1002/cmdc.202100324. Epub 2021 Aug 10. ChemMedChem. 2021. PMID: 34101375 Review.

8

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: brenk r. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

9

On the hunt for metalloenzyme inhibitors: Investigating the presence of metal-coordinating compounds in screening libraries and chemical spaces.

Schuck B, Brenk R. Schuck B, et al. Among authors: brenk r. Arch Pharm (Weinheim). 2024 Apr;357(4):e2300648. doi: 10.1002/ardp.202300648. Epub 2024 Jan 26. Arch Pharm (Weinheim). 2024. PMID: 38279543

10

Riboswitches as Drug Targets for Antibiotics.

Panchal V, Brenk R. Panchal V, et al. Among authors: brenk r. Antibiotics (Basel). 2021 Jan 5;10(1):45. doi: 10.3390/antibiotics10010045. Antibiotics (Basel). 2021. PMID: 33466288 Free PMC article. Review.

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